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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 691 - 696 (6page)
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α-Enolase is a glycolytic enzyme and a surface receptor forplasminogen. α-Enolase-bound plasminogen promotes tumorcell invasion and cancer metastasis by activating plasmin andconsequently degrading the extracellular matrix degradation.
Therefore, α-enolase and plasminogen are novel targets forcancer therapy. We found that the amino acid sequence of apeptide purified from enzymatic hydrolysates of seahorse hasstriking similarities to that of α-enolase. In this study, we reportthat this peptide competes with cellular α-enolase for plasminogenbinding and suppresses urokinase plasminogen activator(uPA)-mediated activation of plasminogen, which results indecreased invasive migration of HT1080 fibrosarcoma cells. Inaddition, the peptide treatment decreased the expression levelsof uPA compared to that of untreated controls. These resultsprovide new insight into the mechanism by which theseahorse-derived peptide suppresses invasive properties ofhuman cancer cells. Our findings suggest that this peptide couldemerge as a potential therapeutic agent for cancer.
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참고문헌 (20)
참고문헌 신청
Bergmann, S. / 2003 / Identification of a novel plasmin(ogen)-binding motif in surface displayed alpha-enolase of Streptococcus pneumoniae / Mol. Microbiol 49 : 411 ~ 423
Boyle, M. D. / 1997 / Plasminogen activation by invasive human pathogens / Thromb. Haemost 77 : 1 ~ 10
Coleman, J. L / 1999 / Use of the plasminogen activation system by microorganisms / J. Lab. Clin. Med 134 : 567 ~ 576
Del Pozo, V. / 2002 / Gene therapy with galectin-3 inhibits bronchial obstruction and inflammation in antigen-challenged rats through inerleukin-5 gene downregulation / Am.
Ehinger, S. / 2004 / Plasmin(ogen)-binding alpha-enolase from Streptococcus pneumoniae: crystal structure and evaluation of plasmin(ogen)-binding sites / J. Mol. Biol 343 :
Boyle, M. D. / 1997 / Plasminogen activation by invasive human pathogens / Thromb. Haemost 77 : 1 ~ 10
Coleman, J. L / 1999 / Use of the plasminogen activation system by microorganisms / J. Lab. Clin. Med 134 : 567 ~ 576
Del Pozo, V. / 2002 / Gene therapy with galectin-3 inhibits bronchial obstruction and inflammation in antigen-challenged rats through inerleukin-5 gene downregulation / Am.
Ehinger, S. / 2004 / Plasmin(ogen)-binding alpha-enolase from Streptococcus pneumoniae: crystal structure and evaluation of plasmin(ogen)-binding sites / J. Mol. Biol 343 :
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