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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 459 - 473 (15page)
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Neurodegenerative diseases (NDs) often involve the formation of abnormal and toxic protein aggregates, which are thought to be the primary factor in ND occurrence and progression. Aged neurons exhibit marked increases in aggregated protein levels, which can lead to increased cell death in specific brain regions. As no specific drugs/therapies for treating the symptoms or/and progression of NDs are available, obtaining a complete understanding of the mechanism underlying the formation of protein aggregates is needed for designing a novel and efficient removal strategy. Intracellular proteolysis generally involves either the lysosomal or ubiquitin-proteasome system. In this review, we focus on the structure and assembly of the proteasome, proteasome-mediated protein degradation, and the multiple dynamic regulatory mechanisms governing proteasome activity. We also discuss the plausibility of the correlation between changes in proteasome activity and the occurrence of NDs.
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참고문헌 (100)
참고문헌 신청
Sorokin AV / 2009 / Proteasome system of protein degradation and processing / Biochemistry 74:1411~1442
Asano S / 2015 / Proteasome. A molecular census of 26S proteasomes in intact neurons / Science 347:439~442
Groll M / 1997 / Structure of the 20S proteasome from yeast at 2. 4 Å resolution / Nature 386:463~471
Griffin TA / 1998 / Immunoproteasome assembly: cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits / J Exp Med 187:97~104
Kulichkova VA / 2010 / 26S proteasome exhibits endoribonuclease activity controlled by extra-cellular stimuli / Cell Cycle 9:840~849
Asano S / 2015 / Proteasome. A molecular census of 26S proteasomes in intact neurons / Science 347:439~442
Groll M / 1997 / Structure of the 20S proteasome from yeast at 2. 4 Å resolution / Nature 386:463~471
Griffin TA / 1998 / Immunoproteasome assembly: cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits / J Exp Med 187:97~104
Kulichkova VA / 2010 / 26S proteasome exhibits endoribonuclease activity controlled by extra-cellular stimuli / Cell Cycle 9:840~849
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