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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 373 - 377 (5page)
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초록· 키워드
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Triple-negative breast cancer (TNBC) is considered to be a notorious type of cancer due to its aggressive metastatic potential and poor prognosis. Recent evidence suggests that BLT2, a low-affinity LTB4 receptor is critically associated with the phenotypes of TNBC cells, including invasion, metastasis, and survival. Furthermore, in a group of 545 breast cancer patients with metastasis, we observed that the high-BLT2 subgroup had a lower disease-free-survival rate than the low-BLT2 subgroup. Thus, we theorized that anti-BLT2 strategies could facilitate the development of new therapies used for TNBC. This review focuses on recent discoveries regarding BLT2 and its roles in as a novel prognostic biomarker in TNBC.
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등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Anders CK / 2010 / Poly(ADP-Ribose) polymerase inhibition: "targeted" therapy for triple-negative breast cancer / Clin Cancer Res 16:4702~4710
Carey L / 2010 / Triple-negative breast cancer: disease entity or title of convenience? / Nat Rev Clin Oncol 7:683~692
Kassam F / 2009 / Survival outcomes for patients with metastatic triple-negative breast cancer: implications for clinical practice and trial design / Clin Breast Cancer 9:29~33
Dinarello CA / 2006 / The paradox of pro-inflammatory cytokines in cancer / Cancer Metastasis Rev 25:307~313
Tager AM / 2003 / BLT1 and BLT2: the leukotriene B(4) receptors / Prostaglandins Leukot Essent Fatty Acids 69:123~134
Carey L / 2010 / Triple-negative breast cancer: disease entity or title of convenience? / Nat Rev Clin Oncol 7:683~692
Kassam F / 2009 / Survival outcomes for patients with metastatic triple-negative breast cancer: implications for clinical practice and trial design / Clin Breast Cancer 9:29~33
Dinarello CA / 2006 / The paradox of pro-inflammatory cytokines in cancer / Cancer Metastasis Rev 25:307~313
Tager AM / 2003 / BLT1 and BLT2: the leukotriene B(4) receptors / Prostaglandins Leukot Essent Fatty Acids 69:123~134
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Analysis of opposing histone modifications H3K4me3 and H3K27me3 reveals candidate diagnostic biomarkers for TNBC and gene set prediction combination
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