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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 103 - 108 (6page)
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Trichomoniasis caused by the parasitic protozoan Trichomonasvaginalis is the most common sexually transmitted diseasein the world. Dendritic cells are antigen presenting cellsthat initiate immune responses by directing the activation anddifferentiation of naïve T cells. In this study, we analyzed theeffect of Trichomonas vaginalis-derived Secretory Products onthe differentiation and function of dendritic cells. Differentiationof bone marrow-derived dendritic cells in the presence ofT. vaginalis-derived Secretory Products resulted in inhibition oflipopolysaccharide-induced maturation of dendritic cells,down-regulation of IL-12, and up-regulation of IL-10. The proteincomponents of T. vaginalis-derived Secretory Products wereshown to be responsible for altered function of bone marrow-derived dendritic cells. Chromatin immunoprecipitationassay demonstrated that IL-12 expression was regulated at thechromatin level in T. vaginalis-derived Secretory Productstreateddendritic cells. Our results demonstrated that T. vaginalis-derived Secretory Products modulate the maturation andcytokine production of dendritic cells leading to immunetolerance.
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참고문헌 (24)
참고문헌 신청
Banchereau J / 2000 / Immunobiology of dendritic cells / Annu Rev Immunol 18 : 767 ~ 811
Chang JH / 2006 / Apoptosis of macrophages induced by Trichomonas vaginalis through the phosphorylation of p38 mitogen-activated protein kinase that locates at downstream of
Cobb MH / 1995 / How MAP kinases are regulated / J Biol Chem 270 : 14843 ~ 14846
Cotch MF / 1997 / Trichomonas vaginalis associated with low birth weight and preterm delivery. The Vaginal Infections and Prematurity Study Group / Sex Transm Dis 24 : 353 ~
Eun-Ju Chang / 2004 / Trichomonas vaginalis Inhibits Proinflammatory Cytokine Production in Macrophages by Suppressing NF-kB Activation / Molecules and Cells 18 (2) : 177 ~
Chang JH / 2006 / Apoptosis of macrophages induced by Trichomonas vaginalis through the phosphorylation of p38 mitogen-activated protein kinase that locates at downstream of
Cobb MH / 1995 / How MAP kinases are regulated / J Biol Chem 270 : 14843 ~ 14846
Cotch MF / 1997 / Trichomonas vaginalis associated with low birth weight and preterm delivery. The Vaginal Infections and Prematurity Study Group / Sex Transm Dis 24 : 353 ~
Eun-Ju Chang / 2004 / Trichomonas vaginalis Inhibits Proinflammatory Cytokine Production in Macrophages by Suppressing NF-kB Activation / Molecules and Cells 18 (2) : 177 ~
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