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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 693 - 699 (7page)
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Together with protein tyrosine kinases (PTKs), protein tyrosine phosphatases (PTPs) serve as hallmarks in cellular signal transduction by controlling the reversible phosphorylation of their substrates. The human genome is estimated to encode more than 100 PTPs, which can be divided into eleven sub-groups according to their structural and functional characteristics. All the crystal structures of catalytic domains of sub-groups have been elucidated, enabling us to understand their precise catalytic mechanism and to compare their structures across all sub-groups. In this review, I describe the structure and mechanism of catalytic domains of PTPs in the structural context. [BMB Reports 2012; 45(12): 693-699]
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참고문헌 (27)
참고문헌 신청
Almo, S. C. / 2007 / Structural genomics of protein phosphatases / J. Struct. Funct. Genomics 8 : 121 ~ 140
Alonso, A. / 2004 / Protein tyrosine phosphatases in the human genome / Cell 117 : 699 ~ 711
Anderson, J. N. / 2001 / Structural and evolutionary relationships among protein tyrosine phosphatase domains / Mol. Cell. Biol. 21 : 7117 ~ 7136
Barford, D. / 1994 / Crystal structure of human protein tyrosine phosphatase 1B / Science 263 : 1397 ~ 1404
Barford, D. / 1998 / The structure and mechanism of protein phosphatases: insights into catalysis and regulation / Annu. Rev. Biophys. Biomol. Struct. 27 : 133 ~ 164
Alonso, A. / 2004 / Protein tyrosine phosphatases in the human genome / Cell 117 : 699 ~ 711
Anderson, J. N. / 2001 / Structural and evolutionary relationships among protein tyrosine phosphatase domains / Mol. Cell. Biol. 21 : 7117 ~ 7136
Barford, D. / 1994 / Crystal structure of human protein tyrosine phosphatase 1B / Science 263 : 1397 ~ 1404
Barford, D. / 1998 / The structure and mechanism of protein phosphatases: insights into catalysis and regulation / Annu. Rev. Biophys. Biomol. Struct. 27 : 133 ~ 164
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