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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 429 - 434 (6page)
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Endometriosis is the abnormal growth of endometrial cells outside the uterus, causing pelvic pain and infertility. Furthermore, adhesion of endometrial tissue fragments to pelvic mesothelium is required for the initial step of endometriosis formation outside uterus. TGF-β1 and adhesion molecules importantly function for adhesion of endometrial tissue fragments to mesothelium outside uterus. However, the function of TGF-β1 on the regulation of adhesion molecule expression for adhesion of endometrial tissue fragments to mesothelium has not been fully elucidated. Interestingly, transforming growth factor β1 (TGF-β1) expression was higher in endometriotic epithelial cells than in normal endometrial cells. The adhesion efficiency of endometriotic epithelial cells to mesothelial cells was also higher than that of normal endometrial cells. Moreover, TGF-β1 directly induced the adhesion of endometrial cells to mesothelial cells through the regulation of integrin of αV, α6, β1, and β4 via the activation of the TGF-β1/TGF-βRI/Smad2 signaling pathway. Conversely, the adhesion of TGF-β1-stimulated endometrial cells to mesothelial cells was clearly reduced following treatment with neutralizing antibodies against specific TGF-β1-mediated integrins αV, β1, and β4 on the endometrial cell membrane. Taken together, these results suggest that TGF-β1 may act to promote the initiation of endometriosis by enhancing integrin-mediated cell-cell adhesion.
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참고문헌 (46)
참고문헌 신청
Honda E / 2010 / Transforming growth factor-beta upregulates the expression of integrin and related proteins in MRC-5 human myofibroblasts / Tohoku J Exp Med 220:319~327
Moyano JV / 2010 / Autocrine transforming growth factor- {beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells / Mol Biol Cell 21:3654~3668
Young VJ / 2014 / The peritoneum is both a source and target of TGF-beta in women with endometriosis / PLoS One 9:e106773
Witz CA / 1999 / Whole explants of peritoneum and endometrium: a novel model of the early endometriosis lesion / Fertil Steril 71:56~60
Witz CA / 2002 / Culture of menstrual endometrium with peritoneal explants and mesothelial monolayers confirms attachment to intact mesothelial cells / Hum Reprod 17:2832~2838
Moyano JV / 2010 / Autocrine transforming growth factor- {beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells / Mol Biol Cell 21:3654~3668
Young VJ / 2014 / The peritoneum is both a source and target of TGF-beta in women with endometriosis / PLoS One 9:e106773
Witz CA / 1999 / Whole explants of peritoneum and endometrium: a novel model of the early endometriosis lesion / Fertil Steril 71:56~60
Witz CA / 2002 / Culture of menstrual endometrium with peritoneal explants and mesothelial monolayers confirms attachment to intact mesothelial cells / Hum Reprod 17:2832~2838
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