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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 219 - 224 (6page)
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The cell-fate specification of the anchor cell (AC) and a ventral uterine precursor cell (VU) in Caenorhabditis elegans is initiated by a stochastic interaction between LIN-12/Notch receptor and LAG-2/Delta ligand in two neighboring Z1.ppp and Z4.aaa cells. Both cells express lin-12 and lag-2 before specification, and a small difference in LIN-12 activity leads to the exclusive expressions of lin-12 in VU and lag-2 in the AC,through a feedback mechanism of unknown nature. Here we show that the expression pattern of lag-1/CSL, a transcriptional repressor itself that turns into an activator upon binding of the intracellular domain of Notch, overlaps with that of lin-12.
Site-directed mutagenesis of LAG-1 binding sites in lag-1maintains its expression in the AC, and eliminates it in the VU.
Thus, AC/VU cell-fate specification appears to involve direct regulation of lag-1 expression by the LAG-1 protein, activating its transcription in VU cells, but repressing it in the AC.
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참고문헌 (24)
참고문헌 신청
Artavanis-Tsakonas, S. / 1999 / Notch signaling: cell fate control and signal integration in development / Science 284 : 770 ~ 776
Bailey, A. M / 1995 / Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity / Genes Dev 9 : 2609 ~
Brenner, S. / 1974 / The genetics of Caenorhabditis elegans / Genetics 77 : 71 ~ 94
Castro, B. / 2005 / Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless / Development 132 : 3333 ~ 3344
Christensen, S. / 1996 / lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H) / Development 122
Bailey, A. M / 1995 / Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity / Genes Dev 9 : 2609 ~
Brenner, S. / 1974 / The genetics of Caenorhabditis elegans / Genetics 77 : 71 ~ 94
Castro, B. / 2005 / Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless / Development 132 : 3333 ~ 3344
Christensen, S. / 1996 / lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H) / Development 122
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