지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 474 - 479 (6page)
이용수
초록· 키워드
오류제보하기
used in the treatment of HCC, but many patients will ultimately relapse with cisplatin-resistant disease. Used in combination with cisplatin, resveratrol has synergistic effect of increasing chemosensitivity of cisplatin in various cancer cells. However, the mechanisms of resveratrol enhancing cisplatininduced toxicity have not been well characterized. Our study showed that resveratrol enhances cisplatin toxicity in human hepatoma cells via an apoptosis-dependent mechanism. Further studies reveal that resveratrol decreases the absorption of glutamine and glutathione content by reducing the expression of glutamine transporter ASCT2. Flow cytometric analyses demonstrate that resveratrol and cisplatin combined treatment leads to a significant increase in ROS production compared to resveratrol or cisplatin treated hepatoma cells alone. Phosphorylated H2AX (H2AX) foci assay demonstrate that both resveratrol and cisplatin treatment result in a significant increase of H2AX foci in hepatoma cells, and the resveratrol and cisplatin combined treatment results in much more H2AX foci formation than either resveratrol or cisplatin treatment alone. Furthermore, our studies show that over-expression of ASCT2 can attenuate cisplatin-induced ROS production, H2AX foci formation and apoptosis in human hepatoma cells. Collectively, our studies suggest resveratrol may sensitize human hepatoma cells to cisplatin chemotherapy via glutamine metabolism inhibition.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Llovet JM / 2004 / Treatment of hepatocellular carcinoma / Curr Treat Options Gastroenterol 7:431~441
Llovet JM / 2002 / Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomized controlled trial / Lancet 359:1734~1739
Lo CM / 2002 / Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma / Hepatology 35:1164~1171
Murata S / 2014 / Interventional treatment for unresectable hepatocellular carcinoma / World J Gastroenterol 20:13453~13465
Shaaban S / 2014 / Chemotherapeutic agent for the treatment of hepatocellular carcinoma: efficacy and mode of action / Oncol Rev 8:25~35
Llovet JM / 2002 / Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomized controlled trial / Lancet 359:1734~1739
Lo CM / 2002 / Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma / Hepatology 35:1164~1171
Murata S / 2014 / Interventional treatment for unresectable hepatocellular carcinoma / World J Gastroenterol 20:13453~13465
Shaaban S / 2014 / Chemotherapeutic agent for the treatment of hepatocellular carcinoma: efficacy and mode of action / Oncol Rev 8:25~35
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Early potential effects of resveratrol supplementation on skeletal muscle adaptation involved in exercise-induced weight loss in obese mice
BMB Reports
2018 .01
-
Identification of a novel PARP4 gene promoter CpG locus associated with cisplatin chemoresistance
BMB Reports
2023 .06
-
API5 induces cisplatin resistance through FGFR signaling in human cancer cells
Experimental and Molecular Medicine
2017 .01
-
유방암세포 성장과 Bmi-1 발현에 대한 레스베라트롤의 억제 효과
KSBB Journal
2017 .09
-
MiR-363 inhibits cisplatin chemoresistance of epithelial ovarian cancer by regulating snail-induced epithelial-mesenchymal transition
BMB Reports
2018 .01
-
Zeb1 for RCP-induced oral cancer cell invasion and its suppression by resveratrol
Experimental and Molecular Medicine
2020 .01
-
A network meta-analysis of the short-term efficacy of five chemotherapy regimens based on cisplatin and fluorouracil for esophagogastric junctional adenocarcinoma
Experimental and Molecular Medicine
2017 .01
-
Multi-layered Microfluidic Drug Screening Platform Enabling Simultaneous Generation of Linear and Logarithmic Concentration Gradients
BioChip Journal
2024 .09
-
Enhanced modified Agarose hydrogels with Resveratrol for Retinal Pigment Epithelial cells regeneration
한국고분자학회 학술대회 연구논문 초록집
2019 .04
-
Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis
Experimental and Molecular Medicine
2017 .01
-
Upregulation of Fas in epithelial ovarian cancer reverses the development of resistance to Cisplatin
BMB Reports
2015 .01
-
Targeting glutamine metabolism as a therapeutic strategy for cancer
Experimental and Molecular Medicine
2023 .04
-
Chemical Inhibition of Cell Recovery after Irradiation with Sparsely and Densely Ionizing Radiation
방사선산업학회지
2016 .01
-
Glutamine reliance in cell metabolism
Experimental and Molecular Medicine
2020 .09
-
Co-Encapsulation of Resveratrol And Cellulase Into ZIF-8 To Optimize Antibacterial And Anticancer Activity
한국생물공학회 학술대회
2023 .10
-
Cancer cells undergoing epigenetic transition show short-term resistance and are transformed into cells with medium-term resistance by drug treatment
Experimental and Molecular Medicine
2020 .01
-
Regulation of IL-6 signaling by miR-125a and let-7e in endothelial cells controls vasculogenic mimicry formation of breast cancer cells
BMB Reports
2019 .01
-
Coordinative Double Hydrophilic Polyether Micelle for Controlled Delivery of Cisplatin
한국고분자학회 학술대회 연구논문 초록집
2023 .04
-
Pre-activation of HIF-1α Using PHD Inhibitor Reduces Cisplatin-induced Nephrotoxicity
한국생물공학회 학술대회
2021 .10
-
Transgelin is Associated with Cisplatin-resistance in the CD133 (+) Subpopulation of HT-29 Human Colon Cancer Cell Line
한국생물공학회 학술대회
2015 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0