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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 229 - 233 (5page)
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초록· 키워드
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The central nervous system (CNS) controls food intake and energy expenditure via tight coordinations between multiple neuronal populations. Specifically, two distinct neuronal populations exist in the arcuate nucleus of hypothalamus (ARH): the anorexigenic (appetite-suppressing) pro-opiomelanocortin (POMC) neurons and the orexigenic (appetiteincreasing) neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons. The coordinated regulation of neuronal circuit involving these neurons is essential in properly maintaining energy balance, and any disturbance therein may result in hyperphagia/obesity or hypophagia/starvation. Thus, adequate knowledge of the POMC and NPY/AgRP neuron physiology is mandatory to understand the pathophysiology of obesity and related metabolic diseases. This review will discuss the history and recent updates on the POMC and NPY/AgRP neuronal circuits, as well as the general anorexigenic and orexigenic circuits in the CNS.
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참고문헌 (50)
참고문헌 신청
Xu Y / 2010 / A serotonin and melanocortin circuit mediates D-fenfluramine anorexia / J Neurosci 30:14630~14634
Smith SR / 2010 / Multicenter, placebo-controlled trial of lorcaserin for weight management / New Engl J Med 363:245~256
Balthasar N / 2004 / Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis / Neuron 42:983~991
Berglund ED / 2012 / Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice / J Clin Invest 122:1000~1009
Scott MM / 2011 / Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice / J Clin Invest 121:2413~2421
Smith SR / 2010 / Multicenter, placebo-controlled trial of lorcaserin for weight management / New Engl J Med 363:245~256
Balthasar N / 2004 / Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis / Neuron 42:983~991
Berglund ED / 2012 / Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice / J Clin Invest 122:1000~1009
Scott MM / 2011 / Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice / J Clin Invest 121:2413~2421
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