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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 413 - 418 (6page)
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DEPDC1 is a recently identified novel tumor-related gene that is upregulated in several types of cancer and contributes to tumorigenesis. In this study, we have investigated the expression pattern and functional implications of DEPDC1 during cell cycle progression. Expression studies using synchronized cells demonstrated that DEPDC1 is highly expressed in the mitotic phase of the cell cycle. Immunofluorescence assays showed that DEPDC1 is predominantly localized in the nucleus during interphase and is redistributed into the whole cell upon nuclear membrane breakdown in metaphase. Subsequently, siRNA-mediated knockdown of DEPDC1 caused a significant mitotic arrest. Moreover, knockdown of DEPDC1 resulted in remarkable mitotic defects such as abnormal multiple nuclei and multipolar spindle structures accompanied by the upregulation of the A20 gene as well as several cell cycle-related genes such as CCNB1 and CCNB2. Taken together, our current observations strongly suggest that this novel cancerous gene, DEPDC1, plays a pivotal role in the regulation of proper mitotic progression.
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참고문헌 (20)
참고문헌 신청
Almuedo-Castillo M / 2014 / JNK controls the onset of mitosis in planarian stem cells and triggers apoptotic cell death required for regeneration and remodeling / PLoS Genet
Bu Y / 2010 / NFBD1/MDC1participates in the regulation of G2/M transition in mammalian cells / Biochem Biophys Res Commun 397 : 157 ~ 162
Cude K / 2007 / Regulation of the G2-M cell cycle progression by the ERK5-NF?B signaling pathway / J Cell Biol 177 : 253 ~ 264
Denning DP / 2014 / Anti-tubulins DEPendably induce apoptosis / Nat Cell Biol 16 : 741 ~ 743
Harada Y / 2010 / Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells / Cancer Res 70 : 5829 ~ 5839
Bu Y / 2010 / NFBD1/MDC1participates in the regulation of G2/M transition in mammalian cells / Biochem Biophys Res Commun 397 : 157 ~ 162
Cude K / 2007 / Regulation of the G2-M cell cycle progression by the ERK5-NF?B signaling pathway / J Cell Biol 177 : 253 ~ 264
Denning DP / 2014 / Anti-tubulins DEPendably induce apoptosis / Nat Cell Biol 16 : 741 ~ 743
Harada Y / 2010 / Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells / Cancer Res 70 : 5829 ~ 5839
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