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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 401 - 406 (6page)
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Here we report that the H3K9 demethylase KDM3B represses transcription of the angiogenesis regulatory gene, ANGPT1.
Negative regulation of ANGPT1 by KDM3B is independent of its Jumonji (JmjC) domain-mediated H3K9 demethylase activity. We demonstrate that KDM3B downregulates ANGPT1 via interaction with SMRT, and suggest that the repressor complex is formed at the promoter area of ANGPT1. Using MTT and wound healing assays, depletion of KDM3B was found to increase cell proliferation and cell motility, indicating that KDM3B has a role in angiogenesis.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Cho CH / 2006 / COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model / Proc Natl Acad Sci U S A 10
Davis S / 1996 / Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning / Cell 87 : 1161 ~ 1169
Ding H / 2001 / Expression and hypoxic regulation of angiopoietins in human astrocytomas / Neuro Oncol 3 : 1 ~ 10
Eggert A / 2000 / High-level expression of angiogenic factors is associated with advanced tumor stage in human neuroblastomas / Clin Cancer Res 6 : 1900 ~ 1908
Feldman N / 2006 / G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis / Nat Cell Biol 8 : 188 ~ 194
Davis S / 1996 / Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning / Cell 87 : 1161 ~ 1169
Ding H / 2001 / Expression and hypoxic regulation of angiopoietins in human astrocytomas / Neuro Oncol 3 : 1 ~ 10
Eggert A / 2000 / High-level expression of angiogenic factors is associated with advanced tumor stage in human neuroblastomas / Clin Cancer Res 6 : 1900 ~ 1908
Feldman N / 2006 / G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis / Nat Cell Biol 8 : 188 ~ 194
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