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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 460 - 465 (6page)
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초록· 키워드
오류제보하기
Polycystic kidney disease (PKD) is one of the most common inherited disorders, involving progressive cyst formation in the kidney that leads to renal failure. FK506 binding protein 12 (FK506BP) is an immunophilin protein that performs multiple functions, including regulation of cell signaling pathways and survival. In this study, we determined the roles of PEP-1- FK506BP on cell proliferation and cyst formation in PKD cells.
Purified PEP-1-FK506BP transduced into PKD cells markedly inhibited cell proliferation. Also, PEP-1-FK506BP drastically inhibited the expression levels of p-Akt, p-p70S6K, p-mTOR, and p-ERK in PKD cells. In a 3D-culture system, PEP-1- FK506BP significantly reduced cyst formation. Furthermore, the combined effects of rapamycin and PEP-1-FK506BP on cyst formation were markedly higher than the effects of individual treatments. These results suggest that PEP-1-FK506BP delayed cyst formation and could be a new therapeutic strategy for renal cyst formation in PKD.
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참고문헌 (24)
참고문헌 신청
Al-Bhalal L / 2008 / Molecular basis of autosomal recessive polycystic kidney disease (ARPKD) / Adv Anat Patho 15 : 54 ~ 58
Bae WY / 2015 / Cinnamic aldehyde suppresses hypoxia-induced angiogenesis via inhibition of hypoxia-inducible factor-1alpha expression during tumor progression / Biochem Pha
Canaud G / 2010 / Therapeutic mTOR inhibition in autosomal dominant polycystic kidney disease: what is the appropriate serum level? / Am J Transplant 10 : 1701 ~ 1706
Candiano G / 1992 / Extracellular matrix formation by epithelial cells from human polycystic kidney cysts in culture / Virchows Arch B Cell Pathol Incl Mol Pathol 63 : 1 ~ 9
Fukuda R / 2002 / Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase an
Bae WY / 2015 / Cinnamic aldehyde suppresses hypoxia-induced angiogenesis via inhibition of hypoxia-inducible factor-1alpha expression during tumor progression / Biochem Pha
Canaud G / 2010 / Therapeutic mTOR inhibition in autosomal dominant polycystic kidney disease: what is the appropriate serum level? / Am J Transplant 10 : 1701 ~ 1706
Candiano G / 1992 / Extracellular matrix formation by epithelial cells from human polycystic kidney cysts in culture / Virchows Arch B Cell Pathol Incl Mol Pathol 63 : 1 ~ 9
Fukuda R / 2002 / Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase an
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