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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 496 - 503 (8page)
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The human body loses several billions of cells daily. When cells die in vivo, the corpse of each dead cell is immediately cleared. Specifically, dead cells are efficiently recognized and cleared by multiple types of neighboring phagocytes. Early research on cell death focused more on molecular mechanisms of cell death regulation while the cellular corpses were merely considered cellular debris. However, it has come to light that various biological stimuli following cell death are important for immune regulation. Clearance of normal dead cells occurs silently in immune tolerance. Exogenous or mutated antigens of malignant or infected cells can initiate adaptive immunity, thereby inducing immunogenicity by adjuvant signals. Several pathogens and cancer cells have strategies to limit the adjuvant signals and escape immune surveillance. In this review, we present an overview of the mechanisms of dead cell clearance and its immune regulations.
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참고문헌 (29)
참고문헌 신청
Arandjelovic S / 2015 / Phagocytosis of apoptotic cells in homeostasis / Nat Immunol 16 : 907 ~ 917
Bianconi E / 2013 / An estimation of the number of cells in the human body / Ann Hum Biol 40 : 463 ~ 471
Bonventre JV / 2011 / Cellular pathophysiology of ischemic acute kidney injury / J Clin Invest 121 : 4210 ~ 4221
Chao MP / 2010 / Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma / Cell 142 : 699 ~ 713
Edris B / 2012 / Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma / Proc Natl Acad Sci U S A 109 : 6656 ~ 6661
Bianconi E / 2013 / An estimation of the number of cells in the human body / Ann Hum Biol 40 : 463 ~ 471
Bonventre JV / 2011 / Cellular pathophysiology of ischemic acute kidney injury / J Clin Invest 121 : 4210 ~ 4221
Chao MP / 2010 / Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma / Cell 142 : 699 ~ 713
Edris B / 2012 / Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma / Proc Natl Acad Sci U S A 109 : 6656 ~ 6661
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