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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 226 - 231 (6page)
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At the post-transcriptional and translational levels, microRNA (miRNA) represses protein-coding genes via seed pairing to the 3’ untranslated regions (UTRs) of mRNA. Although working models of miRNA-mediated gene silencing are successfully established using miRNA transfections and knockouts, the regulatory interaction between miRNA and long non-coding RNA (lncRNA) remain unknown. In particular, how the mRNA-resembling lncRNAs with 5’ cap, 3’ poly(A)-tail, or coding features, are regulated by miRNA is yet to be examined.
We therefore investigated the functional interaction between miRNAs and lncRNAs with/without those features, in miRNAtransfected early zebrafish embryos. We observed that the greatest determinants of the miRNA-mediated silencing of lncRNAs were the 5’ cap and 3’ poly(A)-tails in lncRNAs, at both the post-transcriptional and translational levels. The lncRNAs confirmed to contain 5’ cap, 3’ poly(A)-tail, and the canonical miRNA target sites, were observed to be repressed in the level of both RNA and ribosome-protected fragment, while those with the miRNA target sites and without 5’ cap and 3’ poly(A)-tail, were not robustly repressed by miRNA introduction, thus suggesting a role as a miRNA-decoy.
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참고문헌 (28)
참고문헌 신청
Agarwal V / 2015 / Predicting effective microRNA target sites in mammalian mRNAs / eLife 4 : e05005 ~
Baek D / 2008 / The impact of microRNAs on protein output / Nature 455 : 64 ~ 71
Bagga S / 2005 / Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation / Cell 122 : 553 ~ 563
Bartel DP / 2009 / MicroRNAs: target recognition and regulatory functions / Cell 136 : 215 ~ 233
Bazzini AA / 2012 / Ribosome profiling shows that miR-430 reduces translation before causing mRNA decay in zebrafish / Science 336 : 233 ~ 237
Baek D / 2008 / The impact of microRNAs on protein output / Nature 455 : 64 ~ 71
Bagga S / 2005 / Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation / Cell 122 : 553 ~ 563
Bartel DP / 2009 / MicroRNAs: target recognition and regulatory functions / Cell 136 : 215 ~ 233
Bazzini AA / 2012 / Ribosome profiling shows that miR-430 reduces translation before causing mRNA decay in zebrafish / Science 336 : 233 ~ 237
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