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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 479 - 484 (6page)
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초록· 키워드
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In this study, we report that one of the antimicrobial peptides scolopendrasin VII, derived from Scolopendra subspinipes mutilans, stimulates actin polymerization and the subsequent chemotactic migration of macrophages through the activation of ERK and protein kinase B (Akt) activity. The scolopendrasin VII-induced chemotactic migration of macrophages is inhibited by the formyl peptide receptor 1 (FPR1) antagonist cyclosporine H. We also found that scolopendrasin VII stimulate the chemotactic migration of FPR1-transfected RBL-2H3 cells, but not that of vector-transfected cells; moreover, scolopendrasin VII directly binds to FPR1. Our findings therefore suggest that the antimicrobial peptide scolopendrasin VII, derived from Scolopendra subspinipes mutilans, stimulates macrophages, resulting in chemotactic migration via FPR1 signaling, and the peptide can be useful in the study of FPR1-related biological responses.
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참고문헌 (23)
참고문헌 신청
Bae YS / 2001 / Identification of novel chemoattractant peptides for human leukocytes / Blood 97 : 2854 ~ 2862
Bae YS / 2003 / Differential activation of formyl peptide receptor signaling by peptide ligands / Mol Pharmacol 64 : 841 ~ 847
Brechard S / 2008 / Regulation of superoxide production in neutrophils: role of calcium influx / J Leukoc Biol 84 : 1223 ~ 1237
Dai Y / 2005 / IL-4inhibits expression of the formyl peptide receptor gene in mouse peritoneal macrophages / J Interferon Cytokine Res 25 : 11 ~ 19
De Yang / 2000 / LL-37, the neutrophil granule-and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1(FPRL1)as a receptor to chemoattract human per
Bae YS / 2003 / Differential activation of formyl peptide receptor signaling by peptide ligands / Mol Pharmacol 64 : 841 ~ 847
Brechard S / 2008 / Regulation of superoxide production in neutrophils: role of calcium influx / J Leukoc Biol 84 : 1223 ~ 1237
Dai Y / 2005 / IL-4inhibits expression of the formyl peptide receptor gene in mouse peritoneal macrophages / J Interferon Cytokine Res 25 : 11 ~ 19
De Yang / 2000 / LL-37, the neutrophil granule-and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1(FPRL1)as a receptor to chemoattract human per
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