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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 20 - 24 (5page)
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초록· 키워드
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Clustered regularly-interspaced short palindromic repeats (CRISPR) is a new and effective genetic editing tool. CRISPR was initially found in bacteria to protect it from virus invasions. In the first step, specific DNA strands of virus are identified by guide RNA that is composed of crRNA and tracrRNA. Then RNAse III is required for producing crRNA from pre-crRNA. In The second step, a crRNA:tracrRNA:Cas9 complex guides RNase III to cleave target DNA. After cleavage of DNA by CRISPR-Cas9, DNA can be fixed by Non- Homologous End Joining (NHEJ) and Homology Directed Repair (HDR). Whereas NHEJ is simple and random, HDR is much more complex and accurate. Gene editing by CRISPR is able to be applied to various biological field such as agriculture and treating genetic diseases in human.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Aravind L / 2001 / Prokaryotic homologs of the eukaryotic DNA-end-binding protein ku, novel domains in the ku protein and prediction of a prokaryotic doublestrand break repa
Barrangou R / 2007 / Crispr provides acquired resistance against viruses in prokaryotes / Science 315 : 1709 ~ 1712
Bhaya D / 2011 / Crispr-cas systems in bacteria and archaea: Versatile small rnas for adaptive defense and regulation / Annu Rev Genet 45 : 273 ~ 297
Brouns SJ / 2008 / Small crispr rnas guide antiviral defense in prokaryotes / Science 321 : 960 ~ 964
Carte J / 2014 / The three major types of crispr-cas systems function independently in crispr rna biogenesis in streptococcus thermophilus / Mol Microbiol 93 : 98 ~ 112
Barrangou R / 2007 / Crispr provides acquired resistance against viruses in prokaryotes / Science 315 : 1709 ~ 1712
Bhaya D / 2011 / Crispr-cas systems in bacteria and archaea: Versatile small rnas for adaptive defense and regulation / Annu Rev Genet 45 : 273 ~ 297
Brouns SJ / 2008 / Small crispr rnas guide antiviral defense in prokaryotes / Science 321 : 960 ~ 964
Carte J / 2014 / The three major types of crispr-cas systems function independently in crispr rna biogenesis in streptococcus thermophilus / Mol Microbiol 93 : 98 ~ 112
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Effects of clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) protein 9 system-Based Deletion of miR-451 in Mouse Embryonic Stem Cells on Their Self-Renewal and Hematopoietic Differentiation
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