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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 362 - 367 (6page)
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A major feature of type 1 diabetes mellitus (T1DM) is hyperglycemia and dysfunction of pancreatic -cells. In a previous study, we have shown that Tat-DJ-1 protein inhibits pancreatic RINm5F -cell death caused by oxidative stress. In this study, we examined effects of Tat-DJ-1 protein on streptozotocin (STZ)-induced diabetic mice. Wild type (WT) Tat-DJ-1 protein transduced into pancreas where it markedly inhibited pancreatic -cell destruction and regulated levels of serum parameters including insulin, alkaline phosphatase (ALP), and free fatty acid (FFA) secretion. In addition, transduced WT Tat-DJ-1 protein significantly inhibited the activation of NF-B and MAPK (ERK and p38) expression as well as expression of COX-2 and iNOS in STZ exposed pancreas. In contrast, treatment with C106A mutant Tat-DJ-1 protein showed no protective effects. Collectively, our results indicate that WT Tat-DJ-1 protein can significantly ameliorate pancreatic tissues in STZ-induced diabetes in mice.
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등록된 정보가 없습니다.
참고문헌 (50)
참고문헌 신청
Lukic ML / 2014 / New insight into early events in type 1 diabetes: role for islet stem cell exosomes / Diabetes 63:835~837
Daneman D / 2006 / Type 1 diabetes / Lancet 367:847~858
Welters A / 2014 / Diabetes Mellitus;Metabolism of human diseases: organ physiology and pathophysiology / Springer :163~173
Rui L / 2014 / Energy metabolism in the liver / Compr Physiol 4:177~197
Fiorentino TV / 2013 / Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases / Curr Pharm Des 19:5695~5703
Daneman D / 2006 / Type 1 diabetes / Lancet 367:847~858
Welters A / 2014 / Diabetes Mellitus;Metabolism of human diseases: organ physiology and pathophysiology / Springer :163~173
Rui L / 2014 / Energy metabolism in the liver / Compr Physiol 4:177~197
Fiorentino TV / 2013 / Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases / Curr Pharm Des 19:5695~5703
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