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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 211 - 218 (8page)
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초록· 키워드
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Background: Previous observational epidemiological studies have shown inconsistent results on the relationshipbetween hypnotics use and risk of cancer. To determine the association between hypnotics use and risk of cancer,we conducted a meta-analysis of available literature. Methods: We searched databases PubMed, EMBASE, and the bibliographies of relevant articles to locate additionalpublications in February 2016. Three evaluators independently reviewed and selected eligible studies based onpre-determined selection criteria. Results: A total of six observational epidemiological studies including three case-control studies and three cohortstudies, which involved 1,830,434 participants (202,629 hypnotics users and 1,627,805 non-users), were included inthe final analyses. In a random-effects meta-analysis, compared with non-use of hypnotics, the odds ratio for overallhypnotics use was 1.29 for various cancers (95% confidence interval, 1.08–1.53). Subgroup meta-analyses byvarious factors such as study design, type of case-control study, study region, and methodological quality of studyrevealed consistent findings. Conclusion: Our findings from a meta-analysis of low-biased epidemiological studies suggested evidence linkingthe use of hypnotics to an increased risk of cancers. The results should be cautiously interpreted because ofconsiderable heterogeneity with a Higgins I2 value.
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참고문헌 (28)
참고문헌 신청
Nomura K / 2005 / Impact of insomnia on individual health dissatisfaction in Japan, South Korea, and Taiwan / Sleep 28:1328~1332
Ohayon MM / 1998 / Psychotropic medication consumption patterns in the UK general population / J Clin Epidemiol 51:273~283
Miyawaki I / 2003 / Mechanism of clobazam-induced thyroidal oncogenesis in male rats / Toxicol Lett 145:291~301
Kim DH / 2008 / Comparative anticancer effects of flavonoids and diazepam in cultured cancer cells / Biol Pharm Bull 31:255~259
Halapy E / 2006 / Benzodiazepines and risk for breast cancer / Ann Epidemiol 16:632~636
Ohayon MM / 1998 / Psychotropic medication consumption patterns in the UK general population / J Clin Epidemiol 51:273~283
Miyawaki I / 2003 / Mechanism of clobazam-induced thyroidal oncogenesis in male rats / Toxicol Lett 145:291~301
Kim DH / 2008 / Comparative anticancer effects of flavonoids and diazepam in cultured cancer cells / Biol Pharm Bull 31:255~259
Halapy E / 2006 / Benzodiazepines and risk for breast cancer / Ann Epidemiol 16:632~636
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