지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 51 - 58 (8page)
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초록· 키워드
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Background: Serum gamma-glutamyltransferase (GGT) has been suggested as a predictor for development of the metabolic syndrome in non-Korean population, but studies in Korean population are scarce. Therefore, we examined the association between serum GGT levels and the incidence of the metabolic syndrome in Korean male office workers.
Methods: The study population consisted of 32,692 office workers who underwent health checkups in both 2005 and 2009.
A total of 17,583 with elevated GGT levels, the presence of metabolic syndrome, medication history at baseline, and female office workers were excluded. Finally, 15,109 subjects were included in the final analysis. We measured serum GGT levels and individual metabolic components.
Results: As a quartile of serum GGT increased, 4-year follow-up incidence of the metabolic syndrome increased. After adjustment for age, alcohol drinking status and smoking status in 2005, logistic regression analysis showed that the odds ratios (95%confidence interval) for incident metabolic syndrome in 2009 compared to the lowest quartile and upper quartiles were 1.00(reference), 1.57 (1.24-2.00), 2.73 (2.17-3.43), 3.78 (3.02-4.74), and statistically significant (P < 0.001), respectively.
Conclusion: These results showed that the higher serum GGT predicted the future development of metabolic syndrome. In Korean male office workers without the metabolic syndrome, the serum GGT levels despite normal levels were associated with an increased risk of incident metabolic syndrome.
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참고문헌 (21)
참고문헌 신청
Andre P / 2007 / Gamma-glutamyltransferase activity and development of the metabolic syndrome (International Diabetes Federation Definition) in middle-aged men and women: Da
Ceriello A / 2004 / Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common so
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults / 2001 / Executive Summary of The Third Report of The National Cholesterol Education
Freeman DJ / 2002 / C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study / Diabetes 51 :
Jousilahti P / 2000 / Serum gammaglutamyl transferase, self-reported alcohol drinking, and the risk of stroke / Stroke 31 : 1851 ~ 1855
Ceriello A / 2004 / Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common so
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults / 2001 / Executive Summary of The Third Report of The National Cholesterol Education
Freeman DJ / 2002 / C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study / Diabetes 51 :
Jousilahti P / 2000 / Serum gammaglutamyl transferase, self-reported alcohol drinking, and the risk of stroke / Stroke 31 : 1851 ~ 1855
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