지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 207 - 211 (5page)
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초록· 키워드
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Background : We recently encountered a case of typhoid fever in a patient who visited us after travelling India. The patient received ciprofloxacin therapy, but developed typhoid pneumonia and typhoid hepatitis, and nalidixic acid resistance Salmonella Typhi (NARST) was identified. The aim of this study was to assess the in vitro efficacy of several antimicrobial combinations, which are commonly used in clinical practice.
Materials and Methods : Time-kill studies were performed for a clinical NARST strain to evaluate synergy. Synergy was defined as a ≥2 log10 decrease (100-fold drop) in CFU per mL at 24 hours by a drug combination compared to the most active constituent.
Results : The combination regimen of cefotaxime plus ciprofloxacin significantly reduced the bacterial counts (＞3 log CFU) at 3/4 MIC and at 24 hours compared to the ciprofloxacin or cefotaxime alone and showed synergistic effect against a NARST strain.
Conclusions : In conclusion, our time-kill studies showed that ciprofloxacin plus cefotaxime was the best in vitro combination against a NARST. This combination may improve efficacy compared to fluoroquinolone alone in typhoid fever patient with NARST. Time kill studies with more NARST strains and clinical studies are required to test the relevance of our findings
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참고문헌 (18)
참고문헌 신청
/ 2003 / National Committee for Clinical Laboratory Standards. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. 6th ed. Approved standard M7-
/ 2003 / National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial disk susceptibility tests. 8th ed. Approved standard M2-A8, NCCLS, Wayne, PA
Butler T / 2001 / In vitro effects of azithromycin on Salmonella typhi: early inhibition by concentrations less than the MIC and reduction of MIC by alkaline pH and small in
Chapman JS / 1998 / Routes of quinolone permeation in Escherichia coli / Antimicrob Agents Chemother 32 : 438 ~ 442
Chuang YC / 1997 / In vitro synergism between cefotaxime and minocycline against Vibrio vulnificus / Antimicrob Agents Chemother 41 : 2214 ~ 2217
/ 2003 / National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial disk susceptibility tests. 8th ed. Approved standard M2-A8, NCCLS, Wayne, PA
Butler T / 2001 / In vitro effects of azithromycin on Salmonella typhi: early inhibition by concentrations less than the MIC and reduction of MIC by alkaline pH and small in
Chapman JS / 1998 / Routes of quinolone permeation in Escherichia coli / Antimicrob Agents Chemother 32 : 438 ~ 442
Chuang YC / 1997 / In vitro synergism between cefotaxime and minocycline against Vibrio vulnificus / Antimicrob Agents Chemother 41 : 2214 ~ 2217
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