지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 195 - 201 (7page)
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Matrix metalloproteinases (MMPs) have been implicated in tissue development and re-modeling. Dynamic morphological changes of tooth germs reflect involvement of these enzymes during odontogenesis. The present study was performed to investigate expression and localization of MMP-2 and MMP-9, which have been known to have type IV collagenase activities, in rat tooth germs at different developmental stages. MMP-2 expression was increased gradually in the tooth germs from cap to crown staged germs at both transcription and translation levels. The localization of this molecule was detected in secretory ameloblasts and preameloblasts. The strong immunoreactivities were occasionally seen along the basement membrane between ameloblasts (or preameloblasts) and odontoblasts (preodontoblasts).
However, weak reactivity was detected in odontoblasts and reduced enamel epithelium. The level of MMP-9 expression in the tooth germs was higher in cap stage than in crown staged germs at both transcription and translation levels.
They were strongly expressed in both ameloblasts and odontoblasts. Even though reduced enamel epithelium after enamel formation and inner enamel epithelium at the cap stage exhibited weak reactivity, strong reactivity was detected in dental follicles and perifollicular tissues surrounding cap staged germs. These results suggested that MMP-2 may involve degradation of the basement membrane during hard tissue formation, whereas MMP-9 might be involved in remodeling of follicular tissues.
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참고문헌 (25)
참고문헌 신청
Barrett AJ / 1994 / Classification of peptidases / Methods Enzymol 244 : 1 ~ 15
Bartlett JD / 1999 / Proteinases in developing dental enamel / Crit Rev Oral Biol Med 10 (4) : 425 ~ 441
Bartlett JD / 2003 / Delayed tooth eruption in membrane type-1 matrix metalloproteinase deficient mice / Connect Tissue Res 44 (1) : 300 ~ 304
Bourd-Boittin K / 2005 / Matrix metalloproteinases inhibition impairs the processing, formation and mineralization of dental tissues during mouse molar development / Exp Cell
Fanchon S / 2004 / Involvement of matrix metalloproteinases in the onset of dentin mineralization / Eur J Oral Sci 112 : 171 ~ 176
Bartlett JD / 1999 / Proteinases in developing dental enamel / Crit Rev Oral Biol Med 10 (4) : 425 ~ 441
Bartlett JD / 2003 / Delayed tooth eruption in membrane type-1 matrix metalloproteinase deficient mice / Connect Tissue Res 44 (1) : 300 ~ 304
Bourd-Boittin K / 2005 / Matrix metalloproteinases inhibition impairs the processing, formation and mineralization of dental tissues during mouse molar development / Exp Cell
Fanchon S / 2004 / Involvement of matrix metalloproteinases in the onset of dentin mineralization / Eur J Oral Sci 112 : 171 ~ 176
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