지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 121 - 126 (6page)
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Tumor necrosis factor alpha (TNFα) is a multifunctional inflammatory cytokine that regulates various cellular and biological processes. Increased levels of TNFα have been implicated in a number of human diseases including diabetes and arthritis. Sympathetic nervous system stimulation via the beta2-adrenergic receptor (β2AR) in osteoblasts suppresses osteogenic activity. We previously reported that TNFα upregulates β2AR expression in murine osteoblastic cells and that this modulation is associated with TNFα inhibition of osteoblast differentiation. In our present study, we explored whether TNFα induces β2AR expression in human osteoblasts and then identified the downstream signaling pathway.
Our results indicated that β2AR expression was increased in Saos-2 and C2C12 cells by TNFα treatment, and that this increase was blocked by the inhibition of NF-κB activation.
Chromatin immunoprecipitation and luciferase reporter assay results indicated that NF-κB directly binds to its cognate elements on the β2AR promoter and thereby stimulates β2AR expression. These findings suggest that the activation of TNFα signaling in osteoblastic cells leads to an upregulation of β2AR and also that TNFα induces β2AR expression in an NF-κB-dependent manner.
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참고문헌 (18)
참고문헌 신청
Baek K / 2012 / Myeloid Elf-1- like factor stimulates adipogenic differentiation through the induction of peroxisome proliferator-activated receptor gamma expression in bone
Cope AP / 1997 / Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling / J Exp Med 185 : 1573 ~ 1584
El Hadri K / 1996 / Developmental expression and functional activity of beta 1- and beta 3-adrenoceptors in murine 3T3-F442A differentiating adipocytes / Eur J Pharmacol 297
Elefteriou F / 2005 / Leptin regulation of bone resorption by the sympathetic nervous system and CART / Nature 434 : 514 ~ 520
Feve B / 1991 / Atypical beta-adrenergic receptor in 3T3-F442A adipocytes. Pharmacological and molecular relationship with the human beta 3-adrenergic receptor / J Biol Chem
Cope AP / 1997 / Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling / J Exp Med 185 : 1573 ~ 1584
El Hadri K / 1996 / Developmental expression and functional activity of beta 1- and beta 3-adrenoceptors in murine 3T3-F442A differentiating adipocytes / Eur J Pharmacol 297
Elefteriou F / 2005 / Leptin regulation of bone resorption by the sympathetic nervous system and CART / Nature 434 : 514 ~ 520
Feve B / 1991 / Atypical beta-adrenergic receptor in 3T3-F442A adipocytes. Pharmacological and molecular relationship with the human beta 3-adrenergic receptor / J Biol Chem
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