지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 182 - 189 (8page)
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초록· 키워드
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Background: Human metapneumovirus (hMPV) is a relatively recently identified respiratory virus that induces respiratory symptoms similar to those of respiratory syncytial virus infection in children. The characteristics of hMPV-infected adults are unclear because few cases have been reported.
Methods: We conducted a retrospective review of hospitalized adult patients with a positive multiplex real-time polymerase chain reaction assay result from 2012 to 2016 at a single tertiary referral hospital in South Korea. We analyzed clinical characteristics of the enrolled patients and divided patients into an acute respiratory distress syndrome (ARDS) group and a non-ARDS group.
Results: In total, 110 adults were reviewed in this study. Their mean age was 61.4 years, and the majority (n = 105, 95.5%) had comorbidities or were immunocompromised. Most of the patients had pneumonia on chest X-ray (n = 88, 93.6%), 22 (20.0%) had ARDS, and 12 (10.9%) expired during hospitalization. The mortality rate for patients with ARDS was higher than that of the other patients (36.4% vs. 5.7%, P = 0.001). The risk factor for hMPV-associated ARDS was heart failure (odds ratio, 5.24; P = 0.044) and laboratory values were increased blood urea nitrogen and increased C-reactive protein. The acquisition site of infection was divided into community vs. nosocomial; 43 patients (39.1%) had a nosocomial infection. The risk factors for nosocomial infection were an immunocompromised state, malignancy and immunosuppressive treatment.
Conclusions: These data suggest that hMPV is one of the important respiratory pathogens important respiratory pathogen that causes pneumonia/ARDS in elderly, immunocompromised individuals and that it may be transmitted via the nosocomial route.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
ARDS Definition Task Force / 2012 / Acute respiratory distress syndrome: the Berlin Definition / JAMA 307 : 2526 ~ 2533
Boivin G / 2007 / An outbreak of severe respiratory tract infection due to human metapneumovirus in a long-term care facility / Clin Infect Dis 44 : 1152 ~ 1158
Choi EH / 2006 / The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children, 2000-2005 / Clin Infect Dis 43 : 585 ~ 5
Choi SH / 2012 / Viral infection in patients with severe pneumonia requiring intensive care unit admission / Am J Respir Crit Care Med 186 : 325 ~ 332
Contentin L / 2013 / Acute respiratory distress syndrome secondary to human metapneumovirus infection in a young healthy adult / Intensive Care Med 39 : 533 ~ 534
Boivin G / 2007 / An outbreak of severe respiratory tract infection due to human metapneumovirus in a long-term care facility / Clin Infect Dis 44 : 1152 ~ 1158
Choi EH / 2006 / The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children, 2000-2005 / Clin Infect Dis 43 : 585 ~ 5
Choi SH / 2012 / Viral infection in patients with severe pneumonia requiring intensive care unit admission / Am J Respir Crit Care Med 186 : 325 ~ 332
Contentin L / 2013 / Acute respiratory distress syndrome secondary to human metapneumovirus infection in a young healthy adult / Intensive Care Med 39 : 533 ~ 534
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