지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background/Aims:Long-term antiarrhythmic drug therapy remains the principal approach for suppressing atrial fibrillation (AF) and maintaining sinus rhythm. In this study, we examined the differing electrophysiological effects of various antiarrhythmic drugs on the cardiac chamber and atrial selectivity in patients with AF.
Methods:We analyzed 134 patients (60.4 ± 12.5 years, M:F = 1.14:1) who were administered a single antiarrhythmic agent for AF over 6 months: amiodarone (group A), flecainide (group F), or propafenone (group P). The P wave, QRS complex duration and dispersion, and QT interval and its dispersion were evaluated using a standard 12-lead electrocardiogram.
Results:There was no significant difference in age, gender ratio, or associated diseases among the three groups. In group A, Pmax, Pmin, P dispersion, QRSmax, QRSmin, and QRS dispersion were shorter than in groups F and P, whereas Pmax/QRSmax was the highest in group A (A = 1.2, F = 0.9, P = 1.0; p < 0.01). QTcmax and QTcmin were longer in group A, whereas QTc dispersion and the QT peak to end (A = 13.3 ± 11.2, F = 30.7 ± 24.9, P = 31.8 ± 21.6; p < 0.01) were shorter in group A than in the other groups.
Conclusions:Amiodarone had a weaker, but more selective, inhibitory effect on intra-atrial conduction, and inhibited ventricular repolarization more effectively and homogenously than flecainide or propafenone. These differing electrophysiological effects may contribute to the superior effectiveness and safety of amiodarone over flecainide or propafenone. (Korean J Med 2011;80:672-679)
목차
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참고문헌 (22)
참고문헌 신청
Alpert JS / 1988 / Atrial fibrillation: natural history, complications, and management / Annu Rev Med 39 : 41 ~ 52
American Diabetes Association / 2009 / Standards of medical care in diabetes: 2009 / Diabetes Care 32 (Suppl 1) : S13 ~ S61
Antzelevitch C / 2004 / Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties / Circulation 110 : 904 ~ 909
Bazett H / 1920 / An analysis of the time relationships of the heart / Heart Rhythm 7 : 353 ~ 370
Bonanno C / 2010 / Efficacy and safety of catheter ablation versus antiarrhythmic drugs for atrial fibrillation: a meta-analysis of randomized trials / J Cardiovasc Med (Hage
American Diabetes Association / 2009 / Standards of medical care in diabetes: 2009 / Diabetes Care 32 (Suppl 1) : S13 ~ S61
Antzelevitch C / 2004 / Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties / Circulation 110 : 904 ~ 909
Bazett H / 1920 / An analysis of the time relationships of the heart / Heart Rhythm 7 : 353 ~ 370
Bonanno C / 2010 / Efficacy and safety of catheter ablation versus antiarrhythmic drugs for atrial fibrillation: a meta-analysis of randomized trials / J Cardiovasc Med (Hage
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