지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Nonsteroidal anti-inflammatory drugs (NSAIDs) have analgesic, antipyretic, and anti-inflammatory properties and are widelyused for treating musculoskeletal and cardiovascular diseases. Notwithstanding these therapeutic efficacies, gastrointestinaltoxicity is the major health problem associated with NSAID use. NSAID-related peptic ulcers are a well-known complication due todirect mucosal injury and cyclooxygenase inhibition. Risk factors for NSAID-related peptic ulcers include a prior history of pepticulcer; age > 65 years; high-dose NSAID therapy; and concurrent use of aspirin (including low dose), corticosteroids, oranticoagulants. In addition, Helicobacter pylori infection is an independent risk factor; therefore, eradication therapy isrecommended in high-risk patients using NSAIDs. Currently, misoprostol, H2-receptor antagonists, proton pump inhibitors, andCOX-2 selective inhibitors are used to prevent and treat NSAID-related peptic ulcers. Further, strategic approaches are requiredthrough appropriate NSAID use and risk factor stratification to prevent NSAID-related peptic ulcers and associated complications.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Bacchi S / 2012 / Clinical pharmacology of non-steroidal anti-inflammatory drugs: a review / Antiinflamm Antiallergy Agents Med Chem 11 : 52 ~ 64
Gabriel SE / 1991 / Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs: a meta-analysis / Ann Intern Med 115 : 787 ~ 796
Garcia Rodriguez LA / 2001 / Relative risk of upper gastrointestinal complications among users of acetaminophen and nonsteroidal anti-inflammatory drugs / Epidemiology 12 :
Hawkey CJ / 1998 / Omeprazole compared with misoprostol for ulcers associated with nonsteroida
Hernandez-Diaz S / 2000 / Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: an overview of epidemiologic studie
Gabriel SE / 1991 / Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs: a meta-analysis / Ann Intern Med 115 : 787 ~ 796
Garcia Rodriguez LA / 2001 / Relative risk of upper gastrointestinal complications among users of acetaminophen and nonsteroidal anti-inflammatory drugs / Epidemiology 12 :
Hawkey CJ / 1998 / Omeprazole compared with misoprostol for ulcers associated with nonsteroida
Hernandez-Diaz S / 2000 / Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: an overview of epidemiologic studie
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