지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background/Aims: Preoperative N-terminal pro-brain natriuretic peptide (NT-proBNP) is a useful predictor of postoperativecardiovascular complications. The present study investigated whether blood NT-proBNP values are suitable for predictingpostoperative cardiovascular complications after non-cardiac surgery in elderly patients showing normal left ventricular (LV)function on preoperative echocardiograms.
Methods: This study was performed by analyzing the medical records of elderly patients referred to the cardiology department for thepurpose of assessing their cardiac function before orthopedic surgery. Of the patients who underwent echocardiography and NTproBNPassessment simultaneously, 275 patients aged ≥ 70 years and with an LV ejection fraction of ≥ 55% were included in the study.
Results: Major adverse cardiac and cerebrovascular events (MACCEs) occurred in 33 (12%) of the 275 patients, and theNT-proBNP concentration was higher in patients with complications than in those without complications (1,904.20 ± 2,300.23 vs.
530.58 ± 882.27 pg/mL, p < 0.01). The ROC area under the curve was 0.756 (95% confidence interval 0.701-0.805, p < 0.001) withan optimal cutoff of 416.3 pg/mL (69.7% sensitivity, 67.36% specificity). A multivariate analysis showed that a preoperative age of> 80 years (odds ratio, 2.313; p = 0.047) and an increased blood NT-proBNP concentration (odds ratio, 3.189; p = 0.009) wereindependent risk factors for the prediction of MACCEs.
Conclusions: Although elderly patients scheduled to undergo non-cardiac surgery may show normal LV systolic function onechocardiography, measurement of their preoperative blood NT-proBNP concentration is useful for predicting MACCEs occurringafter non-cardiac surgery.
목차
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참고문헌 (21)
참고문헌 신청
Alpert JS / 2000 / Myocardial infarction redefined: a consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the redefin
Cuthbertson BH / 2007 / The utility of B-type natriuretic peptide in predicting postoperative cardiac events and mortality in patients undergoing major emergency non-cardiac
De Lemos JA / 2001 / The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes / N Engl J Med 345 : 1014 ~ 1021
Feringa HH / 2007 / Plasma Nterminal pro-B-type natriuretic peptide as long-term prognostic marker after major vascular surgery / Heart 93 : 226 ~ 231
Gordon AJ / 2003 / Guideline chaos: conflicting recommendations for preoperative cardiac assessment / Am J Cardiol 91 : 1299 ~ 1303
Cuthbertson BH / 2007 / The utility of B-type natriuretic peptide in predicting postoperative cardiac events and mortality in patients undergoing major emergency non-cardiac
De Lemos JA / 2001 / The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes / N Engl J Med 345 : 1014 ~ 1021
Feringa HH / 2007 / Plasma Nterminal pro-B-type natriuretic peptide as long-term prognostic marker after major vascular surgery / Heart 93 : 226 ~ 231
Gordon AJ / 2003 / Guideline chaos: conflicting recommendations for preoperative cardiac assessment / Am J Cardiol 91 : 1299 ~ 1303
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