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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제43권 제5호
- 발행연도
- 2009.1
- 수록면
- 482 - 488 (7page)
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초록· 키워드
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We report here on a rare case of a patient who presented with an extramedullary B lymphoblastic crisis as an initial manifestation of chronic myelogenous leukemia (CML). A 71-year-old man visited the emergency room due to suddenly developed dysarthria and right side weakness. Emergency craniotomy was done under the presumptive diagnosis of subdural hemorrhage. During the operation, a poorly demarcated firm mass was identified in the leptomeningeal space. Microscopically, the majority of the tumor was composed of monotonous immature cells with blast morphology, and these cells were immunoreactive for TdT, CD34, CD10 and CD20, indicating the precursor B-cell phenotype. The peripheral area of the tumor consisted of myeloid cells in various stages of maturation, and these cells were reactive for myeloperoxidase, chloroacetate esterase, CD43 and CD15. FISH analysis using the LSI bcr-abl dual color probe showed gene fusion signals in both the B-lymphoblasts and myeloid cells. The peripheral blood and bone marrow findings were consistent with CML with no evidence of a blast crisis. Cytogenetic study of the bone marrow demonstrated the 46, XY, t(9;22)(q34;q11) chromosome. A diagnosis of extramedullary B lymphoblastic blast crisis in a patient with Philadelphia chromosome-positive CML was made. Despite treatment, the patient died 3 months after he was diagnosed.
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참고문헌 (12)
참고문헌 신청
Altintas A / 2007 / Central nervous system blastic crisis in chronic myeloid leukemia on imatinib mesylate therapy: a case report / J Neurooncol 84 : 103 ~ 105
Calabretta B / 2004 / The biology of CML blast crisis / Blood 103 : 4010 ~ 4022
Eric D / 2006 / Hematopathology-A volume in foundations in diagnostic pathology series / Philadelphia Churchill Livingstone : 455 ~ 468
Ganessan K / 2007 / Biphenotypic extramedullary blast crisis as a presenting manifestation of Philadelphia chromosome-positive CML in a child / Pediatr Hematol Oncol 24 : 195
Ichinohasama R / 2000 / Ph-negative non-Hodgkin’s lymphoma occurring in chronic phase of Ph-positive chronic myelogenous leukemia is defined as a genetically different neopl
Calabretta B / 2004 / The biology of CML blast crisis / Blood 103 : 4010 ~ 4022
Eric D / 2006 / Hematopathology-A volume in foundations in diagnostic pathology series / Philadelphia Churchill Livingstone : 455 ~ 468
Ganessan K / 2007 / Biphenotypic extramedullary blast crisis as a presenting manifestation of Philadelphia chromosome-positive CML in a child / Pediatr Hematol Oncol 24 : 195
Ichinohasama R / 2000 / Ph-negative non-Hodgkin’s lymphoma occurring in chronic phase of Ph-positive chronic myelogenous leukemia is defined as a genetically different neopl
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