지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제37권 제3호
- 발행연도
- 2003.1
- 수록면
- 159 - 165 (7page)
이용수
초록· 키워드
오류제보하기
Background : Proteinase-activated receptor 2 (PAR2) is cleaved, and it is activated by trypsin or mast cell tryptase. PAR2 plays an important role in inflammation. The aim of this study is to examine the potential of PAR2 agonists to modulate TNF-α secretion from the human astrocytoma cell line CCF-STTG1. Methods : PAR2 expression in CCF-STTG1 was examined using reverse transcriptase polymerase chain reaction and immunocytochemistry. The potential
of PAR2 agonists to modulate TNF-α secretion from CCF-STTG1 was examined by enzymelinked immunosorbent assays. Results : CCF-STTG1 expresses PAR2. PAR2 agonists such as trypsin, mast cell tryptase, and activating peptide SLIGKV-NH2 (corresponding to the PAR2 tethered ligand) directly signal CCF-STTG1 to induce the secretion of TNF-α , but not in the
case of the soybean trypsin inhibitor (SBTI) or VKGILS-NH2 (control peptide). Furthermore, the
secretion of TNF-α was significantly reduced in CCF-STTG1 cells pre-treated with either 50 μM PD98059 (mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK)
inhibitor) or 1 μM SB203580 (p38 MAPK inhibitor) 30 min before trypsin stimulation. Conclusions
: These results show that trypsin may induce TNF- secretion through the activation of MEK and p38 MAPK via PAR2 in astrocytoma cell line CCF-STTG1.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Protease-activated Receptor 2 is Associated with Activation of Human Macrophage Cell Line THP-1
Immune Network
2005 .12
-
Inhibition of Trypsin-Induced Mast Cell Activation by Water Fraction of Lonicera japonica
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
Retroviral Vector를 이용한 TNF-$\alpha$ 유전자의 이입이 암세포의 종양괴사인자(TNF) 감수성에 미치는 효과
Tuberculosis and Respiratory Diseases
1994 .01
-
Inhibitory effect of Lonicera Japonica on trypsin-induced inflammatory mediator secretion from human leukemic mast cells
대한약학회 학술대회
2002 .01
-
Differential Effects of TNF-α on the Survival and Apoptosis of Human Granulocytes and the Human Myeloid Leukemia Cell Line
대한의생명과학회지
2013 .06
-
Upregulation of TNF-α by Triglycerides is Mediated by MEK1 Activation in Jurkat T Cells
대한의생명과학회지
2018 .09
-
Retroviral vector를 이용한 종양괴사인자 (TNF-$\alpha$) 유전자 이입 암세포에서 종양괴사인자 수용체의 발현
Tuberculosis and Respiratory Diseases
1997 .01
-
TNF에 대한 내성획득에서 MnSOD의 역할에 관한 연구
Tuberculosis and Respiratory Diseases
1997 .01
-
암세포에서 Retroviral Vector를 이용한 종양괴사인자 유전자 이입후 획득된 종양괴사인자 내성의 기전
Tuberculosis and Respiratory Diseases
1997 .01
-
TNFα Increases the Expression of β2 Adrenergic Receptors in Osteoblasts
International Journal of Oral Biology
2011 .01
-
Acanthoic acid blocks production of pro-inflammatory mediators by inhibiting the ERK activation in trypsin-stimulated human leukemic mast cells
대한약학회 학술대회
2003 .01
-
호흡기계암세포주에서 TNF-$\alpha$ 유전자의 이입이 항암제 감수성에 미치는 효과
Tuberculosis and Respiratory Diseases
1995 .01
-
Protease-Activated Receptor-2 Is Associated with Terminal Differentiation of Epidermis and Eccrine Sweat Glands
Annals of Dermatology
2015 .01
-
Trypsin과 chymotrypsin이 호산구 화학주성 및 활성화에 미치는 효과
Tuberculosis and Respiratory Diseases
1996 .01
-
ERK mediated suppressive effects of Sophora flavescens on Tnf alpha production in BV2 microglial cells
대한본초학회지(본초분과학회지)
2007 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0