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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제51권 제3호
- 발행연도
- 2017.1
- 수록면
- 284 - 291 (8page)
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초록· 키워드
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Background: Intravascular large B-cell lymphoma (IVLBCL) is a rare type of extranodal lymphoma with growth mainly in the lumina of vessels. We studied a small series of IVLBCL and focused on its central nervous system (CNS) involvement. Methods: Searching the medical records of Northwestern Memorial Hospital, we identified five cases of IVLBCL from January 2007 to January 2015. Clinical information, hematoxylin and eosin stained histologic slides and immunohistochemistry studies were reviewed for all cases. Polymerase chain reaction (PCR) analysis for the immunoglobulin (Ig) heavy and light chain gene rearrangement was performed on all five cases. Results: Three of the five cases of IVLBCL were autopsies. Patients’ age ranged from 56 to 84. CNS involvement was present in two cases—in both patients, the CNS involvement showed an extravascular pattern with confluent sheet-like formation. PCR analysis confirmed that in one case the systemic intravascular and CNS extravascular components were clonally identical. Conclusions: In a small case series of IVLBCL, we observed that CNS involvement by IVLBCL often has an extravascular morphology, but is clonally identical to the intravascular counterpart by PCR analysis. As IVLBCL can have a rapidly progressing poor outcome, it should be kept in the differential diagnoses for patients presenting with lymphoma of the CNS. The presence of extravascular growth patterns in the CNS should not exclude IVLBCL as a diagnosis.
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참고문헌 (24)
참고문헌 신청
[학술지(정기간행물)] -
/ 1986 / Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 39-1986. A 66-year-old woman with fever, fluctuating neurologic signs
Beal MF / 1982 / Neoplastic angioendotheliosis / J Neurol Sci 53 : 359 ~ 375
Campo E / 2011 / The 2008 WHO classification of lymphoid neoplasms and beyond : evolving concepts and practical applications / Blood 117 : 5019 ~ 5032
Demirer T / 1994 / Four varied cases of intravascular lymphomatosis and a literature review / Cancer 73 : 1738 ~ 1745
/ 1986 / Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 39-1986. A 66-year-old woman with fever, fluctuating neurologic signs
Beal MF / 1982 / Neoplastic angioendotheliosis / J Neurol Sci 53 : 359 ~ 375
Campo E / 2011 / The 2008 WHO classification of lymphoid neoplasms and beyond : evolving concepts and practical applications / Blood 117 : 5019 ~ 5032
Demirer T / 1994 / Four varied cases of intravascular lymphomatosis and a literature review / Cancer 73 : 1738 ~ 1745
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