지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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DNA profiling with sets of short tandem repeat (STR) markers is the most popular method for identifying human DNA in forensics. Identification by STR typing might fail when DNA is degraded or is present in low amounts, such as in disaster victim identification (DVI) samples. In such cases, more information might be obtained by using additional markers such as single nucleotide polymorphisms (SNPs). Multiplex PCR and microarray are convenient techniques to analyze SNP markers. We used an AccuID™ Chip, SNP-based DNA chip manufactured by DNA Link Corporation, to confirm genetic relationship between two human bone samples that had been buried for more than 50 years and blood samples from the alleged descendants of the sources of the bone fragments. The chip combines an Affymetrix resequencing array with a multiplex PCR technology and can genotype hundreds of SNP markers in a single experiment. Genotyping the two bone samples yielded 90.5 and 77 SNP markers.
The commonly genotyped markers (61 and 47 SNP loci) in each bone-family pair provided high paternity indices to support the genetic relationships in both cases.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Amorim A / 2005 / Pros and cons in the use of SNPs in forensic kinship investigation: a comparative analysis with STRs / Forensic Sci Int 150 : 17 ~ 21
Butler JM / 2007 / STRs vs. SNPs: thoughts on the future of forensic DNA testing / Forensic Sci Med Pat 3 : 200 ~ 205
Dixon LA / 2006 / Analysis of artificially degraded DNA using STRs and SNPs-results of a collaborative European (EDNAP) exercise / Forensic Sci Int 164 : 33 ~ 44
Fung W / 2008 / Statistical DNA forensics: theory, methods and computation (statistics in practice) / John Wiley and Sons, Ltd : 47 ~ 78
Gross A / 2011 / Population-genetic comparison of the Sorbian isolate population in Germany with the German KORA population using genome-wide SNP arrays / BMC Genet 12 : 67 ~
Butler JM / 2007 / STRs vs. SNPs: thoughts on the future of forensic DNA testing / Forensic Sci Med Pat 3 : 200 ~ 205
Dixon LA / 2006 / Analysis of artificially degraded DNA using STRs and SNPs-results of a collaborative European (EDNAP) exercise / Forensic Sci Int 164 : 33 ~ 44
Fung W / 2008 / Statistical DNA forensics: theory, methods and computation (statistics in practice) / John Wiley and Sons, Ltd : 47 ~ 78
Gross A / 2011 / Population-genetic comparison of the Sorbian isolate population in Germany with the German KORA population using genome-wide SNP arrays / BMC Genet 12 : 67 ~
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