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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제41권 제2호
- 발행연도
- 2007.1
- 수록면
- 79 - 86 (8page)
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Background : Midkine (MK) is a member of the heparin-binding growth factor family. Overexpression
of MK is observed not only in cancerous tissue but also in precancerous lesions
of the colon and the prostate. Using immunohistochemical methods, we investigated MK expression
in preinvasive and invasive neoplasia of the uterine cervix. Methods : We performed immunohistochemical
analysis of archived cone biopsy and hysterectomy specimens from 161
squamous cell lesions of the uterine cervix (29 cervical intraepithelial neoplasia 1 (CIN1), 35
CIN2, 49 CIN3, 30 microinvasive squamous cell carcinomas (MIC), and 18 invasive squamous
cell carcinoma). In addition, we examined if there is a correlation between MK expression and
status of human papilloma virus infection determined by a commercially available DNA chip.
Results : None of the normal cervical mucosa showed MK immunostaining. The level of MK
expression gradually increased according to the histologic grade. Moderate and strong expressions
were most frequently observed in cervical tissue with CIN3 and MIC. MK immunostaining
was more accentuated in the invasive border of MIC. Conclusion : MK may play a functional
role in the disease progression of cervical squamous cell neoplasia.
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참고문헌 (29)
참고문헌 신청
/ 1984 / Concomitant synthesis of growth factorsand their receptors:an aspect of malignant transformation 33 : 941 ~ 3
/ 1988 / cDNA cloning andsequencing of a new gene intensely expressed in early differentiationstages of embryonal carcinoma cells and in mid-gestation periodof mouse embryoge
/ 1991 / Growth factors and cancer 254 : 1146 ~ 53
/ 1991 / Growth factors in development,transformation,and tumorigenesis 64 : 271 ~ 80
/ 1993 / A new family of heparinbinding growth/differentiation factors:increased midkine expressionin Wilms’ tumor and other human carcinomas 53 : 1281 ~ 5
/ 1988 / cDNA cloning andsequencing of a new gene intensely expressed in early differentiationstages of embryonal carcinoma cells and in mid-gestation periodof mouse embryoge
/ 1991 / Growth factors and cancer 254 : 1146 ~ 53
/ 1991 / Growth factors in development,transformation,and tumorigenesis 64 : 271 ~ 80
/ 1993 / A new family of heparinbinding growth/differentiation factors:increased midkine expressionin Wilms’ tumor and other human carcinomas 53 : 1281 ~ 5
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