지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제45권 제6호
- 발행연도
- 2011.1
- 수록면
- 596 - 603 (8page)
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초록· 키워드
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Background: Mutations of c-MYC have been described in cervical cancer. However, association between c-MYC gene status and its prognostic significance have not been clarified. Methods: Tissue microarray sections from 144 patients with stage IB-IIB cervical cancer treated by radical hysterectomy were analyzed by fluorescence in situ hybridization using a region-specific probe for c-MYC and a centromere-specific probe for chromosome 8. Results: Seventy five percent (108/144) of c-MYC gain and 6.9% (10/144) of c-MYC gene amplification were observed. c-MYC gene alteration was more frequently observed in squamous cell carcinoma than adenocarcinoma or adenosquamous carcinoma and were associated with low Ki67 labeling index (p=0.013). c-MYC amplification was not associated with clinicopathologic parameters except absence of bcl2 expression (p=0.048). Survival analysis revealed that patients with c-MYC amplification were sig-nificantly associated with higher risk of disease recurrence (p=0.007) and cancer related death (p=0.020). However, c-MYC gain was not associated with unfavorable outcome. Multivariate analysis proved c-MYC amplification as independent prognostic factors of shorter disease free survival and cancer-related death (p=0.028 and p=0.025, respectively). Conclusions: c-MYC amplification, not gain, is an independent prognostic marker for shorter disease free and cancer specific survival in cervical cancer treated by radical hysterectomy.
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참고문헌 (24)
참고문헌 신청
Berns EM / 1992 / c-myc amplification is a better prognostic factor than HER2/neu amplification in primary breast cancer / Cancer Res 52 : 1107 ~ 1113
Cher ML / 1994 / Comparative genomic hybridization, allelic imbalance, and fluorescence in situ hybridization on chromosome 8 in prostate cancer / Genes Chromosomes Cancer 1
Choschzick M / 2010 / Amplification of 8q21 in breast cancer is independent of MYC and associated with poor patient outcome / Mod Pathol 23 : 603 ~ 610
Couturier J / 1991 / Integration of papillomavirus DNA near myc genes in genital carcinomas and its consequences for proto-oncogene expression / J Virol 65 : 4534 ~ 4538
Ferber MJ / 2003 / Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma / Oncogene 22 : 7233 ~ 7242
Cher ML / 1994 / Comparative genomic hybridization, allelic imbalance, and fluorescence in situ hybridization on chromosome 8 in prostate cancer / Genes Chromosomes Cancer 1
Choschzick M / 2010 / Amplification of 8q21 in breast cancer is independent of MYC and associated with poor patient outcome / Mod Pathol 23 : 603 ~ 610
Couturier J / 1991 / Integration of papillomavirus DNA near myc genes in genital carcinomas and its consequences for proto-oncogene expression / J Virol 65 : 4534 ~ 4538
Ferber MJ / 2003 / Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma / Oncogene 22 : 7233 ~ 7242
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