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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제42권 제2호
- 발행연도
- 2008.1
- 수록면
- 75 - 80 (6page)
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초록· 키워드
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Background : Embryonic lethal abnormal vision (ELAV)-like protein HuR is known to stabilize
mRNA through binding AU-rich elements in the 3’-untranslated region. Recent studies show
that HuR expression is associated with the expression of several genes including cyclooxygenase-
2 (COX-2). HuR exists predominantly in the nucleus, but cytoplasmic translocation of
HuR is thought to be more important for its activity. COX-2 is a well-known enzyme that promotes
tumor growth. Methods : To evaluate the correlation of HuR and COX-2 expression,
we analyzed expression of HuR and COX-2 in 91 cases of breast cancer using immunohistochemistry.
Results : Nuclear and cytoplasmic expression of HuR was seen in 76 (83.5%)
and 19 (20.9%) of 91 cases respectively. COX-2 immunoreactivity was seen in 54 (59.4%)
cases. Cytoplasmic HuR expression showed significant correlation with COX-2 expression
(p=0.001). Nuclear HuR showed no correlation with COX-2 expression or other clinicopathological
parameters. COX-2 expression is significantly associated with tumor grade (p=0.028).
COX-2 (p=0.092) and cytoplasmic (p=0.569) and nuclear HuR (p=0.247) expression showed
no correlation with survival. Conclusions : These results suggest that cytoplasmic HuR expression
is associated with COX-2 expression in breast cancer and cytoplasmic location of HuR
might contribute to the stabilization of COX-2 mRNA.
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참고문헌 (24)
참고문헌 신청
[학술지
Barreau C / 2005 / AU-rich elements and associated factors: are there unifying principles? / Nucleic Acids Res 33 : 7138 ~ 7150
Brennan CM / 2001 / HuR and mRNA stability / Cell Mol Life Sci 58 : 266 ~ 277
Chen CY / 1995 / AU-rich elements: characterization and importance in mRNA degradation / Trends Biochem Sci 20 : 465 ~ 470
Denkert C / 2003 / Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma /
Barreau C / 2005 / AU-rich elements and associated factors: are there unifying principles? / Nucleic Acids Res 33 : 7138 ~ 7150
Brennan CM / 2001 / HuR and mRNA stability / Cell Mol Life Sci 58 : 266 ~ 277
Chen CY / 1995 / AU-rich elements: characterization and importance in mRNA degradation / Trends Biochem Sci 20 : 465 ~ 470
Denkert C / 2003 / Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma /
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Cytoplasmic Expression of HuR is Related to Cyclooxygenase-2 Expression in Colon Cancer
Cancer Research and Treatment
2009 .01
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Expression of Cyclooxygenase-2 and Embryonic Lethal Abnormal Vision- Like Protein HuR in Gallbladder Carcinoma
Journal of Pathology and Translational Medicine
2010 .01
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Downregulation of HuR Inhibits the Progression of Esophageal Cancer through Interleukin-18
Cancer Research and Treatment
2018 .01
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許郢, 許鄢 兄弟名醫의 家傳行蹟과 醫藥事實
한국한의학연구원 논문집
2009 .04
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유방암 조직의 Cox-2 발현
Annals of Surgical Treatment and Research
2009 .12
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Expression of Cyclooxygenase-2 and its Relationship to p53 Accumulation in Colorectal Cancers
Yonsei Medical Journal
2007 .01
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Expression of HuR and Cyclooxygenase-2 in Nodular Fasciitis and Low-Grade Sarcoma: An Immunohistochemical Study
Journal of Pathology and Translational Medicine
2014 .01
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Expression of Cyclooxygenase-2 in Human Breast Cancer: Relationship with HER-2/neu and other Clinicopathological Prognostic Factors
Cancer Research and Treatment
2005 .01
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COX-2 Expression in Renal Cell Carcinoma and Correlations with Tumor Grade, Stage and Patient Prognosis
Asian Pacific journal of cancer prevention : APJCP
2016 .01
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전이성 대장암 환자에서 동시성 및 이시성 간전이 종양의 Cyclooxygenase (COX)-1과 Cyclooxygenase (COX)-2 및 E-cadherin 발현의 의의
Annals of Surgical Treatment and Research
2010 .03
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Cyclooxygenase-2 Expression is not a Marker of Poor Survival in Lung Cancer
Asian Pacific journal of cancer prevention : APJCP
2012 .01
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인간 자궁내막에서 Cyclooxygenase-1과 -2의 주기적 발현 양상
대한불임학회잡지
1998 .01
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COX-2 억제제의 구조-활성
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2001 .01
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Effects of natural extracts on COX-1 and COX-2 mRNA expression on UVB-induced skin inflammation in C57BL/6 mouse
한국환경보건학회지
2006 .01
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TNF-α Up-regulated the Expression of HuR, a Prognostic Marker for Ovarian Cancer and Hu Syndrome, in BJAB Cells
Immune Network
2004 .09
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Expression of Cyclooxygenase-2 Protein in Gastric Carcinogenesis
Cancer Research and Treatment
2002 .01
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유방조직의 c-kit와 COX-2의 발현과 의의
Journal of Pathology and Translational Medicine
2008 .01
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Cyclooxygenase-2 and p53 Expression as Prognostic Indicators in Conventional Renal Cell Carcinoma
Yonsei Medical Journal
2005 .01
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한국인과 백인 젊은 여성 유방암 환자에서 Cyclooxygenase-2 발현과 HER-2/neu 증폭의 비교 연구
Radiation oncology journal : ROJ
2004 .01
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Correlation between COX-2 Expression and Hormone Receptors in Invasive Ductal Breast Cancer
Annals of Surgical Treatment and Research
2010 .03
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