지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제47권 제5호
- 발행연도
- 2013.1
- 수록면
- 418 - 425 (8page)
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Background: Mitotic arrest deficiency protein 2 (MAD2) is a key component of spindle assembly checkpoint function, which mediates cell apoptosis through microtubule kinetics. Aberrant expression of MAD2 is believed to be associated with the development of chromosome instability. MAD2 also has a signihicant role in cellular drug resistance to taxane chemotherapeutic agents. Methods: Expression of MAD2 and p53 was investigated using immunohistochemistry in 85 cases of ovarian carcinomas. Clinicopathological data including progression-free survival were analyzed. Results: A significant (p=.035) association was observed between the grade of serous carcinoma and the expression level of MAD2. While low-grade serous carcinoma showed a lowlevel expression of MAD2, high-grade serous carcinoma showed a high-level expression of MAD2. We also determined that low-level expression of MAD2 was associated with reduced progression-free survival (PFS) (p=.016) in high-grade serous carcinoma. Conclusions: MAD2 expression in ovarian carcinoma is related to the grade of serous carcinoma and PFS of high-grade serous carcinoma. Expression level of MAD2 detected by immunohistochemistry may serve as an indicator in predicting the response of microtubule-interfering chemotherapeutic agents.
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참고문헌 (21)
참고문헌 신청
Arik D / 2011 / p53, bcl-2, and nm23 expressions in serous ovarian tumors: correlation with the clinical and histopathological parameters / Turk Patoloji Derg 27 : 38 ~ 45
Chen X / 2002 / Gene expression patterns in human liver cancers / Mol Biol Cell 13 : 1929 ~ 1939
Fung MK / 2006 / Role of MEK/ERK pathway in the MAD2-mediated cisplatin sensitivity in testicular germ cell tumour cells / Br J Cancer 95 : 475 ~ 484
Fung MK / 2007 / MAD2 expression and its significance in mitotic checkpoint control in testicular germ cell tumour / Biochim Biophys Acta 1773 : 821 ~ 832
Furlong F / 2012 / Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer / J Pathol 226 :
Chen X / 2002 / Gene expression patterns in human liver cancers / Mol Biol Cell 13 : 1929 ~ 1939
Fung MK / 2006 / Role of MEK/ERK pathway in the MAD2-mediated cisplatin sensitivity in testicular germ cell tumour cells / Br J Cancer 95 : 475 ~ 484
Fung MK / 2007 / MAD2 expression and its significance in mitotic checkpoint control in testicular germ cell tumour / Biochim Biophys Acta 1773 : 821 ~ 832
Furlong F / 2012 / Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer / J Pathol 226 :
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