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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제46권 제1호
- 발행연도
- 2012.1
- 수록면
- 1 - 9 (9page)
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Gastric cancers arise through a multistep process characterized by the progressive accumulation of molecular alterations in which genetic and epigenetic mechanisms have been implicated. Gastric cancer is one of the human malignancies in which aberrant promoter CpG island hypermethylation is frequently found. Helicobacter pylori and Epstein-Barr virus, which are known carcinogens for gastric cancer, are closely associated with enhanced hypermethylation of CpG island loci in gastric non-neoplastic epithelial cells and cancer cells, respectively. Aberrant CpG island hypermethylation occurs early in the multistep cascade of gastric carcinogenesis and tends to increase with the step-wise progression of the lesion. Approximately 400 genes that are actively expressed in normal gastric epithelial cells are estimated to be inactivated in gastric cancers as a result of promoter CpG island hypermethylation. In this review, a variety of information is summarized regarding CpG island hypermethylation in gastric cancer.
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참고문헌 (24)
참고문헌 신청
Ahuja N / 1998 / Aging and DNA methylation in colorectal mucosa and cancer / Cancer Res 58 : 5489 ~ 5494
Baylin SB / 1998 / Alterations in DNA methylation: a fundamental aspect of neoplasia / Adv Cancer Res 72 : 141 ~ 196
Chan AO / 2003 / Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer / Gut 52 : 502 ~ 506
Chan AO / 2006 / Eradication of Helicobacter pylori infection reverses E-cadherin promoter hypermethylation / Gut 55 : 463 ~ 468
Drumm B / 1990 / Intrafamilial clustering of Helicobacter pylori infection / N Engl J Med 322 : 359 ~ 363
Baylin SB / 1998 / Alterations in DNA methylation: a fundamental aspect of neoplasia / Adv Cancer Res 72 : 141 ~ 196
Chan AO / 2003 / Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer / Gut 52 : 502 ~ 506
Chan AO / 2006 / Eradication of Helicobacter pylori infection reverses E-cadherin promoter hypermethylation / Gut 55 : 463 ~ 468
Drumm B / 1990 / Intrafamilial clustering of Helicobacter pylori infection / N Engl J Med 322 : 359 ~ 363
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