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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제51권 제5호
- 발행연도
- 2017.1
- 수록면
- 488 - 498 (11page)
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초록· 키워드
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Background: Meconium aspiration syndrome (MAS) is defined by respiratory distress requiring supplemental oxygen in a meconium-stained neonate. MAS is clinically subclassified as mild, moderate, and severe according to the oxygen requirement. The aims of this study were to compare the histological findings in the placentas of MAS neonates with those of meconium-stained but non-MAS neonates and to analyze the correlation between the severity of MAS and the grade of its histological parameters. Methods: We collected 160 singleton term placentas from neonates with meconium staining at birth from a tertiary medical center, Seoul, Republic of Korea. We reviewed hematoxylin and eosin sections of tissue samples (full-thickness placental disc, chorioamniotic membranes, and umbilical cord). Results: Funisitis was present more frequently in MAS than in non-MAS (p < .01), of which the stage was correlated with the severity of MAS (p < .001). The histological findings consistent with maternal underperfusion and chronic deciduitis were more frequent in MAS than in non-MAS (p < .05). There was a correlation between the degree of chorionic vascular muscle necrosis and the severity of MAS (p < .05). Conclusions: Our results suggest that fetal inflammatory response evidenced by funisitis occurs prenatally in MAS and that the stage of funisitis and of chorionic vascular muscle necrosis may be a predictive marker of the severity of MAS.
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참고문헌 (25)
참고문헌 신청
Ahanya SN / 2005 / Meconium passage in utero: mechanisms, consequences, and management / Obstet Gynecol Surv 60 : 45 ~ 56
Altshuler G / 1992 / Meconium-induced umbilical cord vascular necrosis and ulceration: a potential link between the placenta and poor pregnancy outcome / Obstet Gynecol 79 (
Burgess AM / 1996 / umbilical cord and placenta associated with meconium passage in utero : review of 123 autopsied cases / Pathol Res Pract 192 : 1121 ~ 1128
Cornish JD / 1994 / Failure of acute perinatal asphyxia or meconium aspiration to produce persistent pulmonary hypertension in a neonatal baboon model / Am J Obstet Gynecol
D’Alquen D / 2005 / Activation of umbilical cord endothelial cells and
Altshuler G / 1992 / Meconium-induced umbilical cord vascular necrosis and ulceration: a potential link between the placenta and poor pregnancy outcome / Obstet Gynecol 79 (
Burgess AM / 1996 / umbilical cord and placenta associated with meconium passage in utero : review of 123 autopsied cases / Pathol Res Pract 192 : 1121 ~ 1128
Cornish JD / 1994 / Failure of acute perinatal asphyxia or meconium aspiration to produce persistent pulmonary hypertension in a neonatal baboon model / Am J Obstet Gynecol
D’Alquen D / 2005 / Activation of umbilical cord endothelial cells and
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