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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제41권 제3호
- 발행연도
- 2007.1
- 수록면
- 158 - 164 (7page)
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Background : Claudins are important components of the tight junctions in the intercellular barriers
and cell polarity. Among them, claudin-7 is down-regulated in breast cancers compared
with the normal breast epithelium. The aim of this study was to determine the expression pattern
and prognostic value of claudin-7 in breast carcinomas. Methods : Claudin-7 expression
was evaluated immunohistochemically in 42 cases of ductal carcinoma in situ (DCIS) and in
142 cases of invasive breast carcinoma (IBC) using a tissue microarray (TMA). Results : Claudin-
7 was strongly expressed in the normal luminal epithelial cells in the breast lobule. The
level of claudin-7 expression was significantly lower or absent in 45.2% (19/42) of DCIS and
72.5% (103/142) of IBC. A loss or reduced expression of claudin-7 correlated with the invasiveness
(p=0.001) of breast carcinomas and a high nuclear grade (p=0.013) in IBC. Conclusion
: Claudin-7 is an important tight junction protein in the breast and a loss of expression
may assist in the dissociation and invasion of tumor cells.
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참고문헌 (25)
참고문헌 신청
/ / Ellis IO. Pathological prognostic factors in breast cancer.I. The value of histological grade in breast cancer experience froma large study with long-term follow-up. His
/ / et al. Expression of E-cadherincell adhesion molecules in human breast cancer tissues and its relationshipto metastasis. Cancer Res 1993 : 1696 ~ 701
/ 1997 / Consensus conference on the classification of ductal carcinoma in situ 80 : 1798 ~ 1802
/ 1998 / Molecular architecture of tight junctions 60 : 121 ~ 142
/ 1999 / An immunohistochemical examination of the expression of E-cadherin, alpha- and beta/ gamma-catenins, and alpha2- and beta1-integrins in invasive breast cancer 187 :
/ / et al. Expression of E-cadherincell adhesion molecules in human breast cancer tissues and its relationshipto metastasis. Cancer Res 1993 : 1696 ~ 701
/ 1997 / Consensus conference on the classification of ductal carcinoma in situ 80 : 1798 ~ 1802
/ 1998 / Molecular architecture of tight junctions 60 : 121 ~ 142
/ 1999 / An immunohistochemical examination of the expression of E-cadherin, alpha- and beta/ gamma-catenins, and alpha2- and beta1-integrins in invasive breast cancer 187 :
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유방암에서 Claudin-1과 ZO-1 단백 발현 감소와 임상- 병리학적 인자와의 연관성
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