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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제47권 제1호
- 발행연도
- 2013.1
- 수록면
- 21 - 27 (7page)
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초록· 키워드
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Background: We summarize our experience in the pathological diagnosis of late complications of liver transplantation (LT) to better understand the causes of late allograft dysfunction in a population mostly composed of patients with hepatitis B virus (HBV) infection. Methods: We reviewed 361 post-transplant liver biopsies from 174 patients who underwent LT and first presented with liver function abnormalities 3 months post-procedure. The underlying diseases included HBV-associated liver disease (77%), toxic or alcoholic liver disease (10.3%), hepatitis C virus (HCV)-associated liver disease (8.6%), primary biliary cirrhosis (1.2%), primary sclerosing cholangitis (1.2%), and metabolic disease (1.7%). Results: The three most common late complications were acute rejection (32.5%), recurrent disease (19.1%), and biliary complication (17.1%). Patients who underwent LT for HBV infection or for drug- or alcohol-related liver disease had a lower incidence of recurring disease than those who underwent transplantation for HCV infection. During post-transplantation months 3-12, acute rejection was the most common cause of allograft dysfunction and recurring disease was the leading cause for allograft dysfunction (p=0.039). The two primary causes of late allograft dysfunction have overlapping histological features, although acute rejection more frequently showed bile duct damage and vascular endothelialitis than recurring HBV infection, and recurring HBV infection had more frequent lobular activity and piecemeal necrosis. Conclusions: The causes of late liver allograft dysfunction are closely associated with the original liver diseases and the period after LT. Careful attention is required for differential diagnosis between acute rejection and recurrent HBV.
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참고문헌 (22)
참고문헌 신청
Adeyi O / 2010 / Liver allograft pathology: approach to interpretation of needle biopsies with clinicopathological correlation / J Clin Pathol 63 : 47 ~ 74
Anand AC / 1995 / Timing, significance, and prognosis of late acute liver allograft rejection / Transplantation 60 : 1098 ~ 1103
Blakolmer K / 1999 / Analysis of the reversibility of chronic liver allograft rejection implications for a staging schema / Am J Surg Pathol 23 : 1328 ~ 1339
Chen J / 2010 / Hepatitis B immunoglobulins and/or lamivudine for preventing hepatitis B recurrence after liver transplantation: a systematic review / J Gastroenterol Hepatol
Demetris AJ / 1986 / Recurrent hepatitis B in liver allograft recipients: differentiation between viral hepatitis B and rejection / Am J Pathol 125 : 161 ~ 172
Anand AC / 1995 / Timing, significance, and prognosis of late acute liver allograft rejection / Transplantation 60 : 1098 ~ 1103
Blakolmer K / 1999 / Analysis of the reversibility of chronic liver allograft rejection implications for a staging schema / Am J Surg Pathol 23 : 1328 ~ 1339
Chen J / 2010 / Hepatitis B immunoglobulins and/or lamivudine for preventing hepatitis B recurrence after liver transplantation: a systematic review / J Gastroenterol Hepatol
Demetris AJ / 1986 / Recurrent hepatitis B in liver allograft recipients: differentiation between viral hepatitis B and rejection / Am J Pathol 125 : 161 ~ 172
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