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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제47권 제2호
- 발행연도
- 2013.1
- 수록면
- 107 - 115 (9page)
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Background: The epidermal growth factor receptor (EGFR) is a surrogate marker for basal-like breast cancer. A recent study suggested that EGFR may be used as a target for breast cancertreatment. Methods: A total of 706 invasive ductal carcinomas (IDC) of the breast were immunophenotyped, and 82 cases with EGFR protein expression were studied for EGFR gene amplification. Results: EGFR protein was expressed in 121 of 706 IDCs (17.1%); 5.9% were of luminal type, 25.3% of epidermal growth factor receptor 2 (HER-2) type, and 79.3% of basal-like tumors. EGFR gene amplification and high polysomy (fluorescent in situ hybridization [FISH]-positive) were found in 18 of 82 cases (22.0%); 41.2% of the HER-2+, EGFR+, cytokeratin 5/6– (CK5/6–) group, 11.2% of the HER-2–, EGFR+, CK5/6– group, and 19.1% of the HER-2–, EGFR+, CK5/6+ group. FISH-positive cases were detected in 8.3% of the EGFR protein 1+ expression cases, 15.9% of 2+ expression cases, and 38.5% of 3+ expression cases. In group 2, the tumors had a high Ki-67 labeling (>60%), but the patients showed better disease-free survival than those with tumors that co-expressed HER-2 or CK5/6. Conclusions: EGFR-directed therapy can be considered in breast cancer patients with EGFR protein overexpression and gene amplification, and its therapeutic implication should be determined in HER-2 type breast cancer patients.
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참고문헌 (28)
참고문헌 신청
Park K / 2007 / EGFR gene and protein expression in breast cancers / Eur J Surg Oncol 33:956~960
Wolff AC / 2007 / American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer / J Clin Oncol 25:118~145
Qian X / 1994 / Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation / Proc Natl Acad Sci U S A 91:1500~1504
Jin Q / 2008 / Cross-talk between the ErbB/HER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer / J Mammary Gland Biol Neoplasia 13:485~498
Zhang D / 2009 / Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer / Clin Cancer Res 15:6639~6648
Wolff AC / 2007 / American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer / J Clin Oncol 25:118~145
Qian X / 1994 / Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation / Proc Natl Acad Sci U S A 91:1500~1504
Jin Q / 2008 / Cross-talk between the ErbB/HER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer / J Mammary Gland Biol Neoplasia 13:485~498
Zhang D / 2009 / Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer / Clin Cancer Res 15:6639~6648
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