지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제1권 제4호
- 발행연도
- 2013.1
- 수록면
- 339 - 343 (5page)
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초록· 키워드
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Purpose: Atopic dermatitis (AD) is a chronic inflammatory skin disorder with a association of genetic, environmental, and immunologic factors in the development of AD. And AD can be classified into IgE mediated and non-IgE mediated. We investigated a difference of clinical characteristics and immune response between the two groups.
Methods: From January 2008 to December 2011, we enrolled 125 children who visited Dong-A University Medical Center and Busan Medical Center, and were diagnosed as AD with the Haniffin and Rajka's criteria. We checked the history of combined asthma and allergic rhinitis and allergic disease of family in patients. We measured serum total IgE, specific IgE by ImmunoCAP or skin prick test. We measured serum interleukin (IL) 4 (IL-4), interferon-γ (IFN-γ), IL-10, and IL-17, which are associated with chronic inflammatory disorder by flow cytometry method (Luminex).
Results: Eighty (64%) were included in the IgE mediated group, while forty-five (36%) were included in the non-IgE mediated group. The frequency of combined allergic disorder and serum total eosinophil count were relatively higher in IgE mediated group (P=0.023, P=0.032). The incidence of a family history in allergic disease and the mean of SCORing Atopic Dermatitis index had no difference between the two groups. Serum IL-4, IFN-γ, IL-10, IL-17 were higher in the IgE mediated group, but there were no statistically significant differences between two groups (P>0.05).
Conclusion: IgE mediated AD showed higher total eosinophil count and higher incidence of bronchial asthma and allergic rhinitis than non IgE mediated AD.
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참고문헌 (26)
참고문헌 신청
[학술지(정기간행물)]
Akdis CA / 1999 / T cells and T cell-derived cytokines as pathogenic factors in the nonallergic form of atopic dermatitis / J Invest Dermatol 113 : 628 ~ 634
Akdis M / 2003 / T helper (Th) 2 predominance in atopic diseases is due to preferential apoptosis of circulating memory/effector Th1 cells / FASEB J 17 : 1026 ~ 1035
Albanesi C / 2000 / Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes /
Bohme M / 2001 / Clinical features of atopic dermatitis at two years of age: a prospective, population-based case-control study / Acta Derm Venereol 81 : 193 ~ 197
Akdis CA / 1999 / T cells and T cell-derived cytokines as pathogenic factors in the nonallergic form of atopic dermatitis / J Invest Dermatol 113 : 628 ~ 634
Akdis M / 2003 / T helper (Th) 2 predominance in atopic diseases is due to preferential apoptosis of circulating memory/effector Th1 cells / FASEB J 17 : 1026 ~ 1035
Albanesi C / 2000 / Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes /
Bohme M / 2001 / Clinical features of atopic dermatitis at two years of age: a prospective, population-based case-control study / Acta Derm Venereol 81 : 193 ~ 197
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