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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제15권 제1호
- 발행연도
- 2005.1
- 수록면
- 1 - 11 (11page)
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Asthma is a chronic allergic inflammatory disease of lung. The initiation and progression of asthma is dependent on the cytokines interleukin(IL)-4 and IL-13 acting through related receptor complexes. Disease pathogenesis is effected by intracellular signaling pathways that couple primarily to specific motifs within the intracellular domain of the IL-4 receptor α chain(IL-4Rα), a subunit that is common to the IL-4 and IL-13 receptor complexes. Neutralizing anti-cytokine strategies have proven to be highly successful on dissecting relevant effector pathways in experimental allergic disease, and are now entering clinical trials in human allergic disorders. Although there have been only a few clinical studies on the effects of cytokine modulators in asthma, this line of research and development appears promising.
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참고문헌 (34)
참고문헌 신청
[학술지(정기간
/ 1989 / A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents,grow
/ 1992 / IL-4 controls the selective endothelium-drive transmigration of eosinophils from allergic individuals 149 : 1432 ~ 8
/ 1993 / Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses 362 : 248 ~ 50
/ 1994 / Interleukin 13,an interleukin 4-like cytokine that acts on monocytes and B cells,but not on T cells 15 : 19 ~ 26
/ 1989 / A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents,grow
/ 1992 / IL-4 controls the selective endothelium-drive transmigration of eosinophils from allergic individuals 149 : 1432 ~ 8
/ 1993 / Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses 362 : 248 ~ 50
/ 1994 / Interleukin 13,an interleukin 4-like cytokine that acts on monocytes and B cells,but not on T cells 15 : 19 ~ 26
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