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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제22권 제4호
- 발행연도
- 2012.1
- 수록면
- 325 - 335 (11page)
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초록· 키워드
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Allergic disorders such as atopic dermatitis and asthma are common hyperimmune disorders in industrialized countries. Although the exact etiology is unclear, several factors may trigger the disease onset. These include susceptible genetic background, environmental factors and an aberrant gut microbiota with a shift of the Th1/Th2 balance towards a Th2 response. Probiotics confer health benefits through multiple action mechanisms including modification of immune system in both systemic immune system and gut associated lymphoid tissue. Although many human clinical trials and mouse studies demonstrated the beneficial effects of probiotics in diverse allergic disorders, therapeutic efficacy is quite diverse depending on administration dose and types of strains or their mixture. To properly modulate allergic diseases, administration of tailor made probiotics with immune tolerance activity is required. Human clinical trials demonstrate a limited benefit of probiotics in atopic dermatitis in a preventive as well as a therapeutic capacity. In addition, beneficial effect of probiotics treatment is limited in the treatment of bronchial asthma. Identification of specific probiotics that has immune modulating activity and elucidation of the underlying mechanism of action will lead to develop probiotics as an as immune modulator targeting allergic disorders. Herein, we briefly review the diverse functions and regulation mechanisms of probiotics in allergic disorders including atopic dermatitis and asthma.
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참고문헌 (43)
참고문헌 신청
Leung DY / 2003 / New concepts in the pathogenesis of atopic dermatitis / Curr Opin Immunol 15:634~638
Kalliomaki M / 2001 / Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing / J Allergy Clin Immunol 107:129~134
Penders J / 2007 / Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study / Gut 56:661~667
Kendler M / 2006 / Comparison of fecal microflora in children with atopic eczema/dermatitis syndrome according to IgE sensitization to food / Pediatr Allergy Immunol 17:141~147
Ouwehand AC / 2007 / Antiallergic effects of probiotics / J Nutr 137(3):794~797
Kalliomaki M / 2001 / Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing / J Allergy Clin Immunol 107:129~134
Penders J / 2007 / Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study / Gut 56:661~667
Kendler M / 2006 / Comparison of fecal microflora in children with atopic eczema/dermatitis syndrome according to IgE sensitization to food / Pediatr Allergy Immunol 17:141~147
Ouwehand AC / 2007 / Antiallergic effects of probiotics / J Nutr 137(3):794~797
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