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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제1권 제3호
- 발행연도
- 2013.1
- 수록면
- 216 - 220 (5page)
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Purpose: Pollinosis is one of the major allergic diseases caused by airborne pollens. Alder and birch pollens are the major sensitizing tree pollens in this country. The immunoglobulin E (IgE) reactivity to each pollen allergen is known to be variable according to the region. We determined the major IgE binding components of these tree pollens in sera of adult patients with allergic rhinitis.
Methods: Allergic rhinitis patients, of whom specific IgE level to birch and/or alder pollens (>10 kU/L by ImmunoCAP) were included. The protein bands of two pollen extracts were determined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis, and their IgE-binding components were identified by IgE immunoblot analysis. The binding specificity and cross-reactivity between two pollens were evaluated by IgE enzyme linked immunosorbent assay (ELISA) inhibition test.
Results: Six IgE binding components were found in birch pollens in which two (14 kDa and 17 kDa) were major components. Two IgE binding components were found in alder pollens in which the 17 kDa was a major component. The IgE binding component to the major allergen component of 17 kDa was observed in 90.3% of the study subjects sensitive to alder pollens and 72.7% of them sensitive to birch pollens. The ELISA inhibition tests showed significant inhibitions with additions of birch/alder pollen extracts.
Conclusion: We identified two major IgE binding components (17 kDa and 14 kDa) from birch pollens and one component (17 kDa) from alder pollens. Significant cross reactivity was noted between these two pollens.
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참고문헌 (19)
참고문헌 신청
/ 2003 / The Angiosperm Phylogeny Group. An update of the angiosperm phylogeny group classification for the orders and families of flowering plants: APG II / Bot J Linn Soc 1
Ebner C / 1995 / Identification of allergens in fruits and vegetables: IgE cross-reactivities with the important birch pollen allergens Bet v 1 and Bet v 2 (birch profilin) /
Huh JE / 2009 / Protective effects of butanol fraction from Betula platyphyla var. japonica on cartilage alterations in a rabbit collagenase-induced osteoarthritis / J Ethno
Jarolim E / 1989 / IgE and IgG antibodies of patients with allergy to birch pollen as tools to define the allergen profile of Betula verrucosa / Allergy 44 : 385 ~ 395
Mothes N / 2004 / Transition from a botanical to a molecular classification in tree pollen allergy: implications for diagnosis and therapy / Int Arch Allergy Immunol 135 : 3
Ebner C / 1995 / Identification of allergens in fruits and vegetables: IgE cross-reactivities with the important birch pollen allergens Bet v 1 and Bet v 2 (birch profilin) /
Huh JE / 2009 / Protective effects of butanol fraction from Betula platyphyla var. japonica on cartilage alterations in a rabbit collagenase-induced osteoarthritis / J Ethno
Jarolim E / 1989 / IgE and IgG antibodies of patients with allergy to birch pollen as tools to define the allergen profile of Betula verrucosa / Allergy 44 : 385 ~ 395
Mothes N / 2004 / Transition from a botanical to a molecular classification in tree pollen allergy: implications for diagnosis and therapy / Int Arch Allergy Immunol 135 : 3
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