지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 36 - 42 (7page)
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Background and Purpose Although plasmapheresis is becoming standard practice as a rescue therapy for neuromyelitis optica (NMO), evidence for the therapeutic efficacy of plasmapheresis is limited, and the effect of plasmapheresis on anti-aquaporin-4 (AQP4) levels in patients with NMO has not been reported. Here, our objective was to evaluate the clinical efficacy of therapeutic plasmapheresis and its effect on anti-AQP4 antibody levels in patients with NMO spectrum disorder (NMOSD).
Methods We retrospectively reviewed the medical records of 15 patients with NMOSD who had 18 acute attacks and received plasmapheresis because they did not respond to high-dose intravenous methylprednisolone (IVMP) therapy. Anti-AQP4 antibodies were measured before and after plasmapheresis. The primary outcomes were functional improvements immediately and 6 months after plasmapheresis, and the secondary outcome was the change in anti-AQP4antibody serum levels following plasmapheresis.
Results Plasmapheresis following IVMP therapy led to significant improvement in 50% of the 18 attacks in 15 patients immediately after the procedure was completed, and in 78% (14attacks) after 6 months. Plasmapheresis was generally well tolerated in all patients. Anti-AQP4antibody serum levels declined significantly following plasmapheresis, to a mean of 15% of the preplasmapheresis levels. Lower scores on the visual outcome scale recorded before an attack were associated with significant immediate improvement upon the completion of plasmapheresis (p=0.03).
Conclusions Plasmapheresis following IVMP therapy effectively removed anti-AQP4 antibodies and was accompanied by a substantial improvement in the neurological disability of patients with NMOSD. Lower levels of pre-existing neurological damage may be associated with an improved acute response to plasmapheresis.
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참고문헌 (25)
참고문헌 신청
[학술지(정기간행물)
Bennett JL / 2009 / Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica / Annals of Neurology 66 : 617 ~ 629
Bonnan M / 2009 / Plasma exchange in severe spinal attacks associated with neuromyelitis optica spectrum disorder / Multiple Sclerosis Journal 15 : 487 ~ 492
Bonnan M / 2012 / Plasma exchange in severe attacks of neuromyelitis optica / Multiple Sclerosis International 2012 : 787630 ~
Bradl M / 2009 / Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo / Annals of Neurology 66 : 630 ~ 643
Bennett JL / 2009 / Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica / Annals of Neurology 66 : 617 ~ 629
Bonnan M / 2009 / Plasma exchange in severe spinal attacks associated with neuromyelitis optica spectrum disorder / Multiple Sclerosis Journal 15 : 487 ~ 492
Bonnan M / 2012 / Plasma exchange in severe attacks of neuromyelitis optica / Multiple Sclerosis International 2012 : 787630 ~
Bradl M / 2009 / Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo / Annals of Neurology 66 : 630 ~ 643
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