지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 133 - 139 (7page)
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Background and Purpose Vascular shear stress is essential for maintaining the morphologyand function of endothelial cells. We hypothesized that shear stress in the internal carotid artery(ICA) may differ between patients with ischemic stroke and healthy control subjects.
Methods ICA shear stress was calculated in 143 controls and 122 patients with ischemicstroke who had a normal ICA or an ICA with <50% stenosis. The stroke group included patientswho presented with a first-ever or recurrent ischemic stroke but excluded cardioembolic strokeand uncertain etiologies. Of the 122 patients, 107 (87.7%) and 15 (12.3%) patients were categorized as first-ever and recurrent stroke, respectively.
Results Carotid diameters were significantly larger, and both peak-systolic and end-diastolicvelocities were significantly lower in patients with ischemic stroke than in controls (all p values<0.05). Mean values of peak-systolic and end-diastolic shear stress in both ICAs were significantly lower in patients with ischemic stroke in models that adjusted for age, sex, and vascularrisk factors (p for trend <0.05). The ICA shear stress was lowest in patients with recurrentstroke or the subtype of small-vessel occlusion. Higher peak-systolic and end-diastolic shearstresses in both ICAs were independently and negatively associated with ischemic stroke afteradjusting for potential confounders (all p values <0.05).
Conclusions ICA shear stresses were significantly lower in patients with ischemic strokethan in control subjects. Future studies should attempt to define the causal relationship betweencarotid arterial shear stress and ischemic stroke.
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참고문헌 (23)
참고문헌 신청
Adams HP Jr / 1993 / Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172in Acute Stroke Treatm
Carallo C / 2006 / Wall shear stress is lower in the carotid artery responsible for a unilateral ischemic stroke / Atherosclerosis 185 : 108 ~ 113
Cho YI / 1991 / Effects of the non-Newtonian viscosity of blood on flows in a diseased arterial vessel. Part 1: Steady flows / Biorheology 28 : 241 ~ 262
Cunningham KS / 2005 / The role of shear stress in the pathogenesis of atherosclerosis / Lab Invest 85 : 9 ~ 23
Giannoglou GD / 2002 / Haemodynamic factors and the important role of local low static pressure in coronary wall thickening / Int J Cardiol 86 : 27 ~ 40
Carallo C / 2006 / Wall shear stress is lower in the carotid artery responsible for a unilateral ischemic stroke / Atherosclerosis 185 : 108 ~ 113
Cho YI / 1991 / Effects of the non-Newtonian viscosity of blood on flows in a diseased arterial vessel. Part 1: Steady flows / Biorheology 28 : 241 ~ 262
Cunningham KS / 2005 / The role of shear stress in the pathogenesis of atherosclerosis / Lab Invest 85 : 9 ~ 23
Giannoglou GD / 2002 / Haemodynamic factors and the important role of local low static pressure in coronary wall thickening / Int J Cardiol 86 : 27 ~ 40
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