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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 446 - 451 (6page)
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Background and Purpose Encephalitis caused by Listeria monocytogenes (L. monocyto¬genes) is rare but sometimes fatal. Early diagnosis is difficult using routine cerebrospinal flu¬id (CSF) tests, while next-generation sequencing (NGS) is increasingly being used for the detection and characterization of pathogens.
Methods This study set up and applied unbiased NGS to detect L. monocytogenes in CSF collected from three cases of clinically suspected listeria meningoencephalitis.
Results Three cases of patients with acute/subacute meningoencephalitis are reported. Magnetic resonance imaging and blood cultures led to a suspected diagnosis of L. monocy¬togenes, while the CSF cultures were negative. Unbiased NGS of CSF identified and se¬quenced reads corresponding to L. monocytogenes in all three cases.
Conclusions This is the first report highlighting the feasibility of applying NGS of CSF as a diagnostic method for central nervous system (CNS) L. monocytogenes infection. Routine application of this technology in clinical microbiology will significantly improve diagnostic methods for CNS infectious diseases.
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등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Workman S / 1997 / Rhomboencephalitis caused by Listeria monocytogenes / Can J Infect Dis 8:113~116
Armstrong RW / 1993 / Brainstem encephalitis (rhombencephalitis)due to Listeria monocytogenes: case report and review / Clin Infect Dis 16:689~702
Mylonakis E / 1998 / Central nervous system infection with Listeria monocytogenes. 33 years’ experience at a general hospital and review of 776 episodes from the literature / Medicine (Baltimore) 77:313~336
Paul ML / 1994 / Listeriosis--a review of eighty-four cases / Med J Aust 160:489~493
Long SW / 2013 / A genomic day in the life of a clinical microbiology laboratory / J Clin Microbiol 51:1272~1277
Armstrong RW / 1993 / Brainstem encephalitis (rhombencephalitis)due to Listeria monocytogenes: case report and review / Clin Infect Dis 16:689~702
Mylonakis E / 1998 / Central nervous system infection with Listeria monocytogenes. 33 years’ experience at a general hospital and review of 776 episodes from the literature / Medicine (Baltimore) 77:313~336
Paul ML / 1994 / Listeriosis--a review of eighty-four cases / Med J Aust 160:489~493
Long SW / 2013 / A genomic day in the life of a clinical microbiology laboratory / J Clin Microbiol 51:1272~1277
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