지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 345 - 350 (6page)
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초록· 키워드
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Background and PurposezzWe assessed the prevalence and potential association of hypertension with multiple sclerosis (MS)-related disability progression.
MethodszzTis was a retrospective study of 2,813 patients who were followed for 20 years.
We modeled the associations of several risk factors with the pattern of disability progression.
Te primary end point was the rate of disability progression.
ResultszzIn total, 2,396 patients were available for analysis, of which 1,074 (44.8%) scored 4 (EDSS4) on the Expanded Disability Status Scale (EDSS), 717 (29.9%) scored 6 (EDSS6), and 261 (10.9%) scored 8 (EDSS8). The mean times to reach scores of 4, 6, and 8 were 123.5, 163.1, and 218.9 months, respectively. Hypertension was present in 207 (8.6%) patients during follow-up. Hypertension was associated with a higher probability of reaching each EDSS score compared to non-hypertensive patients: 62% vs. 43% for EDSS4 (p<0.01), 51% vs. 28% for EDSS6 (p<0.01), and 17% vs. 10% for EDSS8 (p<0.01). Nevertheless, hypertensive MS patients experienced longer intervals to reach each EDSS score: longer by 51.6, 38.9, and 62.7 months to EDSS4, EDSS6, and EDSS8, respectively (p<0.01) when compared to non-hypertensive MS patients reaching the same EDSS scores.
ConclusionszzDisability progression is more prevalent amongst hypertensive MS patients.
However, they experience longer time intervals between the stages of disability progression.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Confavreux C / 2014 / The clinical course of multiple sclerosis / Handb Clin Neurol 122:343~369
Goodin DS / 2014 / The epidemiology of multiple sclerosis: insights to disease pathogenesis / Handb Clin Neurol 122:231~266
Koch M / 2008 / Factors associated with the risk of secondary progression in multiple sclerosis / Mult Scler 14:799~803
Newbould RD / 2014 / Age independently affects myelin integrity as detected by magnetization transfer magnetic resonance imaging in multiple sclerosis / Neuroimage Clin 4:641~648
Tremlett H / 2010 / New perspectives in the natural history of multiple sclerosis / Neurology 74:2004~2015
Goodin DS / 2014 / The epidemiology of multiple sclerosis: insights to disease pathogenesis / Handb Clin Neurol 122:231~266
Koch M / 2008 / Factors associated with the risk of secondary progression in multiple sclerosis / Mult Scler 14:799~803
Newbould RD / 2014 / Age independently affects myelin integrity as detected by magnetization transfer magnetic resonance imaging in multiple sclerosis / Neuroimage Clin 4:641~648
Tremlett H / 2010 / New perspectives in the natural history of multiple sclerosis / Neurology 74:2004~2015
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