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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 155 - 161 (7page)
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초록· 키워드
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Background and Purpose Hypertrophic pachymeningitis (HP) is a rare disease caused by autoimmunity in the meninx that causes various neurologic symptoms, including headache, seizures, weakness, paresthesia, and cranial nerve palsies. Although the first-line therapy for HP is steroids, many HP cases are refractory to steroids or recur when the steroids are ta¬pered. Here we report three HP cases that were successfully treated with rituximab (RTX).
Methods From an institutional cohort recruited from April 2012 to July 2016, three HP cases that were identified to be steroid-refractory were treated with RTX (four weekly doses of 375 mg/m2). Clinical improvement was assessed by the number of relapses of any neurologic symptom and the largest dural thickness in MRI.
Results All three patients were recurrence-free of neurologic symptoms and exhibited promi¬nent decreases in the dural thickness after RTX treatment. No adverse events were observed in the patients.
Conclusions We suggest RTX as a second-line therapy for steroid-refractory HP. Further studies are warranted to confirm this observation in a larger population and to consider RTX as a first-line therapy.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Bosman T / 2008 / Idiopathic hypertrophic cranial pachymeningitis treated by oral methotrexate:a case report and review of literature / Rheumatol Int 28 : 713 ~ 718
Choi IS / 2000 / Combined therapy of corticosteroid and azathioprine in hypertrophic cranial pachymeningitis / Eur Neurol 44 : 193 ~ 198
Hyun JW / 2014 / Steroid-resistant relapsing IgG4-related pachymeningitis treated with methotrexate / JAMA Neurol 71 : 222 ~ 225
Khosroshahi A / 2012 / Rituximab for the treatment of IgG4-related disease: lessons from 10 consecutive patients / Medicine 91 : 57 ~ 66
Kupersmith MJ / 2004 / Idiopathic hypertrophic pachymeningitis / Neurology 62 : 686 ~ 694
Choi IS / 2000 / Combined therapy of corticosteroid and azathioprine in hypertrophic cranial pachymeningitis / Eur Neurol 44 : 193 ~ 198
Hyun JW / 2014 / Steroid-resistant relapsing IgG4-related pachymeningitis treated with methotrexate / JAMA Neurol 71 : 222 ~ 225
Khosroshahi A / 2012 / Rituximab for the treatment of IgG4-related disease: lessons from 10 consecutive patients / Medicine 91 : 57 ~ 66
Kupersmith MJ / 2004 / Idiopathic hypertrophic pachymeningitis / Neurology 62 : 686 ~ 694
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