지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 189 - 196 (8page)
이용수
초록· 키워드
오류제보하기
Dual antiplatelet therapy simultaneously blocks different platelet activation pathways and mightthus be more potent at inhibiting platelet activation and more effective at reducing major ischemic vascular events compared to antiplatelet monotherapy. Aspirin plus clopidogrel dual therapy is now the standard therapy for patients with acute coronary syndrome and for those undergoing percutaneous coronary intervention. However, dual antiplatelet therapy carries an increasedrisk of bleeding. Patients with ischemic stroke or transient ischemic attack (TIA) are generallyolder and likely to have a fragile cerebrovascular bed, which further increases the risk of systemicmajor bleeding events and intracranial hemorrhage. Clinical trials and meta-analyses suggestthat in comparison to antiplatelet monotherapy, dual antiplatelet therapy initiated early afternoncardioembolic ischemic stroke or TIA further reduces the rate of recurrent stroke and majorvascular events without significantly increasing the rate of major bleeding events. In contrast,studies of long-term therapy in patients with noncardioembolic ischemic stroke or TIA haveyielded inconsistent data regarding the benefit of dual antiplatelet therapy over monotherapy.
However, the harm associated with major bleeding events, including intracranial hemorrhage,which is generally more disabling and more fatal than ischemic stroke, is likely to increase withdual antiplatelet therapy. Physicians should carefully assess the benefits and risks of dual antiplatelet therapy versus antiplatelet monotherapy when managing patients with ischemic strokeor TIA.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Antithrombotic Trialists’ Collaboration / 2002 / Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and
Chen ZM / 2005 / Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction:randomised placebo-controlled trial / Lancet 366 : 1607 ~ 1621
Dengler R / 2010 / Early treatment with aspirin plus extended-release dipyridamole for transient ischaemic attack or ischaemic stroke within 24 h of symptom onset (EARLY tri
Geeganage CM / 2012 / Dual or mono antiplatelet therapy for patients with acute ischemic stroke or transient ischemic attack: systematic review and m
Hong KS / 2011 / Declining stroke and vascular event recurrence rates in secondary prevention trials over the past 50 years and consequences for current trial design / Circul
Chen ZM / 2005 / Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction:randomised placebo-controlled trial / Lancet 366 : 1607 ~ 1621
Dengler R / 2010 / Early treatment with aspirin plus extended-release dipyridamole for transient ischaemic attack or ischaemic stroke within 24 h of symptom onset (EARLY tri
Geeganage CM / 2012 / Dual or mono antiplatelet therapy for patients with acute ischemic stroke or transient ischemic attack: systematic review and m
Hong KS / 2011 / Declining stroke and vascular event recurrence rates in secondary prevention trials over the past 50 years and consequences for current trial design / Circul
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