지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 217 - 222 (6page)
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초록· 키워드
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The immune hypothesis of major depressive disorder (MDD) fits well with the supposed interaction between genetic and environmental factors in disorders with a complicated etiopathogenesis. It has been suggested that infectious diseases are associated with MDD in that cytokines may play a critical role as a key modulator in the transition between infection and the development of MDD. It has been also suggested that antidepressants have immunomodulatory effects on some cytokines and cytokine receptors, although the exact mechanism has not yet been fully elucidated. Among cytokines, monocyte chemoattractant protein-1 (MCP-1) is especially well known and has attracted considerable interest owing to its immunomodulatory functions. MCP-1 is expressed in highly regionalized neuronal areas in the brain, leading to kind of modulation of neuronal activity and neuroendocrine functions commonly seen in patients with MDD.
Additionally, it is involved in the control of other cytokines that have been consistently proposed as associated with the development of MDD. It also has a possible role in the neurodegenerative process of a number of central nervous system (CNS) diseases. Hence, this paper draws from the perspective of immunology to offer several suggestions about the role of MPC-1 in the development of MDD.
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참고문헌 (23)
참고문헌 신청
[학술
Abou-Saleh MT / 2006 / Neuroimaging in psychiatry: An update / J Psychosom Res 61 : 289 ~ 293
Banisadr G / 2005 / Highly regionalized neuronal expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) in rat brain: Evidence for its colocalization with neurotransm
Blume J / 2011 / Immune suppression and immune activation in depression / Brain Behav Immun 25 : 221 ~ 229
Fenoglio C / 2004 / MCP-1 in Alzheimer’s disease patients: A-2518G polymorphism and serum levels / Neurobiol Aging 25 : 1169 ~ 1173
Abou-Saleh MT / 2006 / Neuroimaging in psychiatry: An update / J Psychosom Res 61 : 289 ~ 293
Banisadr G / 2005 / Highly regionalized neuronal expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) in rat brain: Evidence for its colocalization with neurotransm
Blume J / 2011 / Immune suppression and immune activation in depression / Brain Behav Immun 25 : 221 ~ 229
Fenoglio C / 2004 / MCP-1 in Alzheimer’s disease patients: A-2518G polymorphism and serum levels / Neurobiol Aging 25 : 1169 ~ 1173
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